In the Adriatic Sea (Mediterranean Sea), during monitoring of Production Water (PW) discharged from offshore platforms, high contamination levels of metals, PAH, and aliphatic hydrocarbons are detected in the sediment close to some installations. Here, we investigate for the first time, the transport and fate of the total suspended solids (TSS) associated with PW discharged by selected platforms, considering the separation of particulate matter from the water plume. We apply a 3D hydrodynamic model and a Lagrangian module to simulate the dispersion of PW suspended substances, then we relate the numerical results to the sediment contamination measured data. The TSS released with PW determines a negligible contribution along the water column and seems poorly related to the anomalies observed in the sediment contamination levels. This approach paves the way to assess the potential risks arising from TSS discharged with the PW on marine ecosystems and to optimize the environmental monitoring tools.