Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields. Multicomponent reactions (MCRs) are highly convergent one-pot processes, in which three or more reagents are combined sequentially to construct complex products, with almost all the atoms coming from the starting reagents. In this context, the syntheses of ‘heterocycles’ via MCR-based processes have been reviewed a number of times. However, there is not a single review (recent or otherwise) covering the synthesis of ‘polyheterocycles’ via a direct MCR or via a one-pot process involving MCRs coupled to further cyclizations (via ionic, metal-catalyzed, pericyclic, or free-radical-mediated cyclizations). This issue is consequently the main topic of the present review, which considers work from the last decade. The work is categorized according to the key processes involved in the syntheses of polyheterocycles, aiming to give readers an easy understanding of this MCR-based chemistry and to provide insights for further investigations. The reaction mechanisms providing novel elements to these MCR-based methods for the synthesis of polyheterocycles are also discussed.

Water and ethanol stabilities of the crystal structure of the Cu-based metal–organic framework (MOF) HKUST-1 have been investigated. Vapour (water and ethanol) sorption isotherms and cyclability were measured by a dynamic strategy. The ethanol sorption capacity of HKUST-1 at 303 K remained unchanged contrasting water sorption (which decreased along with the sorption experiment time). Considering the binding energy of each sorbate with the open Cu(II) sites, obtained by the use of diffusion coefficients, we showed the superior crystal stability of the HKUST-1 framework towards ethanol. Finally, a small quantity of ethanol (pre-adsorbed) slightly enhanced CO₂ capture without crystal structure degradation.

An emerging technology for CO₂ capture is the construction of hybrid adsorbent MOFs via confinement of water inside the pores. This review article describes the recent progress in this field.

A broad variety of α-aminoamide-based compounds have been synthesized via the three-component version of the Ugi reaction (U-3CR) or by any of its variants (Ugi-Zhu-3CR, Orru-3CR, Ugi-4C-3CR, Ugi-Joullié-3CR, GBB-3CR, Ugi-Reissert-3CR, and so on).

Mg-CUK-1 exhibited high chemical stability towards H₂S and H₂O. Monte Carlo Simulations correlated with H₂S uptake.

MFM-300(Sc) was demonstrated to be an optimal adsorbent for SO ₂ capture combining high uptake, good stability and excellent cyclability (facile regeneration at only room temperature). A drastic enhancement on its SO ₂ uptake (40%) was achieved when a small amount of EtOH was preliminary adsorbed.