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Rheum emodi Wall. Ex. Meissen is an important food and medicinal plant growing wild in western Himalayas. The current endeavor was undertaken to carry out bioassay guided fractionation and isolation of antimutagenic principle(s) present in the rhizomes of Rheum emodi. The antimutagenicity assay was performed to check the recuperating effect of 80% aqueous methanol extract of rhizomes of R. emodi and its fractions i.e. n-hexane, chloroform, ethyl acetate, n-butanol and water fractions, against 4-nitro-o-phenylenediamine (NPD), sodium azide, and 2AF-induced mutagenicity in TA98 and TA100 strains using the Ames Salmonella his+ reversion assay. The crude 80% aqueous methanol extract and ethyl acetate fraction exhibited strong antimutagenicity. The antimutagenic potential of the extracts and fractions was markedly enhanced when indirect acting mutagen was used in both the tester strains of Salmonella typhimurium. In an effort to identify the molecules responsible for the antimutagenic effect displayed by R. emodi, four anthraquinones i.e. aloe-emodin, chrysophanol, emodin and rhein detected in the ethyl acetate fraction by HPLC analysis were also tested for their antimutagenic potential in both the tester strains. It was found that the anthraquinones in their pure form showed lower antimutagenicity than the mother fraction from which they were isolated. The results point towards a synergistic effect of the principles present in the mother fraction.
Anjana Bhatia; Saroj Arora; Avinash Nagpal; Bikram Singh. Screening of rhizomes of Rheum emodi Wall. Ex. Meissen for antimutagenic potential employing Ames assay. The Nucleus 2020, 63, 167 -177.
AMA StyleAnjana Bhatia, Saroj Arora, Avinash Nagpal, Bikram Singh. Screening of rhizomes of Rheum emodi Wall. Ex. Meissen for antimutagenic potential employing Ames assay. The Nucleus. 2020; 63 (2):167-177.
Chicago/Turabian StyleAnjana Bhatia; Saroj Arora; Avinash Nagpal; Bikram Singh. 2020. "Screening of rhizomes of Rheum emodi Wall. Ex. Meissen for antimutagenic potential employing Ames assay." The Nucleus 63, no. 2: 167-177.
Plants have been the basis of traditional medicine since the dawn of civilizations. Different plant parts possess various phytochemicals, playing important roles in preventing and curing diseases. Scientists, through extensive experimental studies, are playing an important part in establishing the use of phytochemicals in medicine. However, there are still a large number of medicinal plants which need to be studied for their phytochemical profile. In this study, the objective was to isolate phytochemicals from bark of Bauhinia variegata L. and to study them for their antioxidant and cytotoxic activities. The bark was extracted with methanol, followed by column chromatography and thus isolating kaempferol, stigmasterol, protocatechuic acid-methyl ester (PCA-ME) and protocatechuic acid (PCA). 2,2-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 2, 2’-diphenyl-1-picrylhydrazyl radical (DPPH) radical scavenging assays were utilized for assessment of antioxidant activity, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye reduction assay was used to determine cytotoxic activity against C-6 glioma rat brain, MCF-7 breast cancer, and HCT-15 colon cancer cell lines. The compounds were found to have significant antioxidant and cytotoxic activity. Since there is a considerable increase in characterizing novel chemical compounds from plant parts, the present study might be helpful for chemotaxonomic determinations, for understanding of medicinal properties as well as for the quality assessment of herbal supplements containing B. variegata bark, thus establishing its use in traditional medicine.
Neha Sharma; Anket Sharma; Gaurav Bhatia; Marco Landi; Marian Brestic; Bikram Singh; Jatinder Singh; Satwinderjeet Kaur; Renu Bhardwaj. Isolation of Phytochemicals from Bauhinia variegata L. Bark and Their In Vitro Antioxidant and Cytotoxic Potential. Antioxidants 2019, 8, 492 .
AMA StyleNeha Sharma, Anket Sharma, Gaurav Bhatia, Marco Landi, Marian Brestic, Bikram Singh, Jatinder Singh, Satwinderjeet Kaur, Renu Bhardwaj. Isolation of Phytochemicals from Bauhinia variegata L. Bark and Their In Vitro Antioxidant and Cytotoxic Potential. Antioxidants. 2019; 8 (10):492.
Chicago/Turabian StyleNeha Sharma; Anket Sharma; Gaurav Bhatia; Marco Landi; Marian Brestic; Bikram Singh; Jatinder Singh; Satwinderjeet Kaur; Renu Bhardwaj. 2019. "Isolation of Phytochemicals from Bauhinia variegata L. Bark and Their In Vitro Antioxidant and Cytotoxic Potential." Antioxidants 8, no. 10: 492.
Needles of seven cultivated clones (C1 – C7) of Juniperus communis at lower altitude and three wild Juniperus species (J. communis, J. recurva and J. indica) at higher altitudes were investigated comparatively for their essential oils (EOs) yields, chemical composition, cytotoxic and antibacterial activities. The EOs yields varied from 0.26 to 0.56% (v/w) among samples. Sixty‐one volatile components were identified by gas chromatography‐mass spectrometry (GC/MS) and quantified using gas chromatography GC (FID) representing 82.5 – 95.7% of the total oil. Monoterpene hydrocarbons (49.1 – 82.8%) dominated in all samples (α‐pinene, limonene and sabinene as major components). Principal component analysis (PCA) of GC data revealed that wild and cultivated Juniperus species are highly distinct due to variation in chemical composition. J. communis (wild species) displayed cytotoxicity against SiHa (human cervical cancer), A549 (human lung carcinoma) and A431 (human skin carcinoma) cells (66.4 ± 2.2%, 74.4 ± 1.4% and 57.4 ± 4.0%), respectively, at 200 μg/ml. EOs exhibited better antibacterial activity against Gram‐positive bacteria than against Gram‐negative bacteria with the highest zone of inhibition against Staphylococcus aureus MTCC 96 (19.2 ± 0.7) by clone‐7. As per the conclusion of the findings, EOs of clone‐2, clone‐5 and clone‐7 can be suggested to the growers of lower altitude, as there is more possibility of uses of these EOs in food and medicinal preparations.
Antim K. Maurya; Renuka Devi; Ashish Kumar; Rajkesh Koundal; Soni Thakur; Anamika Sharma; Dharmesh Kumar; Rakshak Kumar; Yogendra Padwad; Gopi Chand; Bikram Singh; Vijai K. Agnihotri. Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species. Chemistry & Biodiversity 2018, 15, e1800183 .
AMA StyleAntim K. Maurya, Renuka Devi, Ashish Kumar, Rajkesh Koundal, Soni Thakur, Anamika Sharma, Dharmesh Kumar, Rakshak Kumar, Yogendra Padwad, Gopi Chand, Bikram Singh, Vijai K. Agnihotri. Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species. Chemistry & Biodiversity. 2018; 15 (9):e1800183.
Chicago/Turabian StyleAntim K. Maurya; Renuka Devi; Ashish Kumar; Rajkesh Koundal; Soni Thakur; Anamika Sharma; Dharmesh Kumar; Rakshak Kumar; Yogendra Padwad; Gopi Chand; Bikram Singh; Vijai K. Agnihotri. 2018. "Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species." Chemistry & Biodiversity 15, no. 9: e1800183.
Vinod Bhatt; Neeraj Kumar; Upendra Sharma; Bikram Singh. Front Cover: Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography. SEPARATION SCIENCE PLUS 2018, 1, 1 .
AMA StyleVinod Bhatt, Neeraj Kumar, Upendra Sharma, Bikram Singh. Front Cover: Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography. SEPARATION SCIENCE PLUS. 2018; 1 (5):1.
Chicago/Turabian StyleVinod Bhatt; Neeraj Kumar; Upendra Sharma; Bikram Singh. 2018. "Front Cover: Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography." SEPARATION SCIENCE PLUS 1, no. 5: 1.
Zanthoxylum armatum and Z. acanthopodium belong to the Rutaceae family, are extensively used in traditional folk medicine and possess anti‐inflammatory, antibacterial, hepatoprotecive and antidiabetic properties. However, the comprehensive phytochemical studies of these species in order to explain medicinal properties are still not clear. In the present study, a new ultra high performance liquid chromatography method has been developed for the determination of the biologically important compounds in the different parts (leaves, bark, flowers and fruits) of Z. armatum and Z. acanthopodium. The results revealed that lignans and flavonoids are the principal components in leaves samples while aporphine alkaloids, lignans and amides are the major constituents in bark samples of Z. armatum. None of the analyzed compounds were detected in bark and leaves of Z. acanthopodium except catechin. In contrast, the fruit pericarp was characterized by the sanshool analogues, especially hydroxy‐α‐sanshool. In addition, the method was also applied for identification of 27 metabolites in the different parts of Z. armatum and Z. acanthopodium using ultra high performance liquid chromatography with tandem mass spectrometry. The identification of eight compounds in Z. armatum and metabolic profiling of Z. acanthopodium is reported here for the first time. The results obtained were also analyzed by principal component analysis to discriminate the similarity and differences among the samples.
Vinod Bhatt; Neeraj Kumar; Upendra Sharma; Bikram Singh. Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography. SEPARATION SCIENCE PLUS 2018, 1, 311 -324.
AMA StyleVinod Bhatt, Neeraj Kumar, Upendra Sharma, Bikram Singh. Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography. SEPARATION SCIENCE PLUS. 2018; 1 (5):311-324.
Chicago/Turabian StyleVinod Bhatt; Neeraj Kumar; Upendra Sharma; Bikram Singh. 2018. "Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using ultra high performance liquid chromatography." SEPARATION SCIENCE PLUS 1, no. 5: 311-324.
The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1–5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.
Manju Bala; Shiv Kumar; Kunal Pratap; Praveen Kumar Verma; Yogendra Padwad; Bikram Singh. Bioactive isoquinoline alkaloids from Cissampelos pareira. Natural Product Research 2017, 33, 622 -627.
AMA StyleManju Bala, Shiv Kumar, Kunal Pratap, Praveen Kumar Verma, Yogendra Padwad, Bikram Singh. Bioactive isoquinoline alkaloids from Cissampelos pareira. Natural Product Research. 2017; 33 (5):622-627.
Chicago/Turabian StyleManju Bala; Shiv Kumar; Kunal Pratap; Praveen Kumar Verma; Yogendra Padwad; Bikram Singh. 2017. "Bioactive isoquinoline alkaloids from Cissampelos pareira." Natural Product Research 33, no. 5: 622-627.
Insecticidal activities of Parthenium hysterophorus L. (PH) studied against Plutella xylostella the major insect pest of cruciferous crops and Aphis craccivora Koch on legume crops. Results showed that PH extract found promising toxicity (LC50 = 1140.68 mg L−1) to larvae of P. xylostella after 96 h of treatment as compared to parthenin (LC50 = 1709.42 mg L−1). Parthenin also showed moderate repellent activity to P. xylostella (43.33 ± 4.18%). However, parthenin is more effective against A. craccivora (LC50 = 839 mg L−1) than PH extract (LC50 = 947.87 mg L−1). Based on field bio-efficacy studies, PH extract can be recommended for the management of target pests.
S. G. Eswara Reddy; Shudh Kirti Dolma; Praveen Kumar Verma; Bikram Singh. Insecticidal activities of Parthenium hysterophorus L. extract and parthenin against diamondback moth, Plutella xylostella (L.) and aphid, Aphis craccivora Koch. Toxin Reviews 2017, 37, 161 -165.
AMA StyleS. G. Eswara Reddy, Shudh Kirti Dolma, Praveen Kumar Verma, Bikram Singh. Insecticidal activities of Parthenium hysterophorus L. extract and parthenin against diamondback moth, Plutella xylostella (L.) and aphid, Aphis craccivora Koch. Toxin Reviews. 2017; 37 (2):161-165.
Chicago/Turabian StyleS. G. Eswara Reddy; Shudh Kirti Dolma; Praveen Kumar Verma; Bikram Singh. 2017. "Insecticidal activities of Parthenium hysterophorus L. extract and parthenin against diamondback moth, Plutella xylostella (L.) and aphid, Aphis craccivora Koch." Toxin Reviews 37, no. 2: 161-165.
Manoranjan Kumar; Sushila Sharma; Krishana Thakur; Onkar S. Nayal; Vinod Bhatt; Maheshwar S. Thakur; Neeraj Kumar; Bikram Singh; Upendra Sharma. Montmorillonite-K10-Catalyzed Microwave-Assisted Direct Amidation of Unactivated Carboxylic Acids with Amines: Maintaining Chiral Integrity of Substrates. Asian Journal of Organic Chemistry 2017, 6, 342 -346.
AMA StyleManoranjan Kumar, Sushila Sharma, Krishana Thakur, Onkar S. Nayal, Vinod Bhatt, Maheshwar S. Thakur, Neeraj Kumar, Bikram Singh, Upendra Sharma. Montmorillonite-K10-Catalyzed Microwave-Assisted Direct Amidation of Unactivated Carboxylic Acids with Amines: Maintaining Chiral Integrity of Substrates. Asian Journal of Organic Chemistry. 2017; 6 (3):342-346.
Chicago/Turabian StyleManoranjan Kumar; Sushila Sharma; Krishana Thakur; Onkar S. Nayal; Vinod Bhatt; Maheshwar S. Thakur; Neeraj Kumar; Bikram Singh; Upendra Sharma. 2017. "Montmorillonite-K10-Catalyzed Microwave-Assisted Direct Amidation of Unactivated Carboxylic Acids with Amines: Maintaining Chiral Integrity of Substrates." Asian Journal of Organic Chemistry 6, no. 3: 342-346.
Sushila Sharma; Manoranjan Kumar; Vinod Bhatt; Onkar S. Nayal; Maheshwar S. Thakur; Neeraj Kumar; Bikram Singh; Upendra Sharma. Vasicine from Adhatoda vasica as an organocatalyst for metal-free Henry reaction and reductive heterocyclization of o-nitroacylbenzenes. Tetrahedron Letters 2016, 57, 5003 -5008.
AMA StyleSushila Sharma, Manoranjan Kumar, Vinod Bhatt, Onkar S. Nayal, Maheshwar S. Thakur, Neeraj Kumar, Bikram Singh, Upendra Sharma. Vasicine from Adhatoda vasica as an organocatalyst for metal-free Henry reaction and reductive heterocyclization of o-nitroacylbenzenes. Tetrahedron Letters. 2016; 57 (45):5003-5008.
Chicago/Turabian StyleSushila Sharma; Manoranjan Kumar; Vinod Bhatt; Onkar S. Nayal; Maheshwar S. Thakur; Neeraj Kumar; Bikram Singh; Upendra Sharma. 2016. "Vasicine from Adhatoda vasica as an organocatalyst for metal-free Henry reaction and reductive heterocyclization of o-nitroacylbenzenes." Tetrahedron Letters 57, no. 45: 5003-5008.
Rohit Arora; Sakshi Bhushan; Rakesh Kumar; Rahul Mannan; Pardeep Kaur; Bikram Singh; Ritika Sharma; Adarsh Pal Vig; Balbir Singh; Amrit Pal Singh; Saroj Arora. To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations. Anti-Cancer Agents in Medicinal Chemistry 2016, 16, 1 -1.
AMA StyleRohit Arora, Sakshi Bhushan, Rakesh Kumar, Rahul Mannan, Pardeep Kaur, Bikram Singh, Ritika Sharma, Adarsh Pal Vig, Balbir Singh, Amrit Pal Singh, Saroj Arora. To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations. Anti-Cancer Agents in Medicinal Chemistry. 2016; 16 (999):1-1.
Chicago/Turabian StyleRohit Arora; Sakshi Bhushan; Rakesh Kumar; Rahul Mannan; Pardeep Kaur; Bikram Singh; Ritika Sharma; Adarsh Pal Vig; Balbir Singh; Amrit Pal Singh; Saroj Arora. 2016. "To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations." Anti-Cancer Agents in Medicinal Chemistry 16, no. 999: 1-1.
Potentilla atrosanguinea is well known for its ethnomedicinal uses since ancient times. The present study includes the isolation of a new nortriterpene, 28-methyl-acanthochlamate (1), from the roots of P. atrosanguinea. The structure of 1 was established from HR-ESI-MS and NMR spectroscopic analysis. Its relative stereochemistry was set with the help of NOESY correlation experiment. Compound (1) has been quantified by a new developed UPLC-DAD method (1.1 mg/g). The in vitro cytotoxicity of the new compound (1) was evaluated by sulforhodamine B assay against three cancer cells; human cervical cancer (SiHa), epidermal carcinoma (KB), and human adenocarcinoma (Colo-205). The new isolated compound (1) showed a significantly higher cytotoxicity against all the cells (SiHa, IC50 30.5 µg/mL; KB, IC50 22.6 µg/mL and Colo-205, IC50 18.8 µg/mL).
Mayanka Walia; Dharmesh Kumar; Bikram Singh; Pawan Kumar; Yogendra Padwad; Vijai Agnihotri. Cytotoxic New Nortriterpene from Roots of Potentilla atrosanguinea var. argyrophylla and its UPLC Quantification. Planta Medica International Open 2016, 3, 1 .
AMA StyleMayanka Walia, Dharmesh Kumar, Bikram Singh, Pawan Kumar, Yogendra Padwad, Vijai Agnihotri. Cytotoxic New Nortriterpene from Roots of Potentilla atrosanguinea var. argyrophylla and its UPLC Quantification. Planta Medica International Open. 2016; 3 (2):1.
Chicago/Turabian StyleMayanka Walia; Dharmesh Kumar; Bikram Singh; Pawan Kumar; Yogendra Padwad; Vijai Agnihotri. 2016. "Cytotoxic New Nortriterpene from Roots of Potentilla atrosanguinea var. argyrophylla and its UPLC Quantification." Planta Medica International Open 3, no. 2: 1.
Reductive N -alkylation through a carbocationic pathway. We report herein a highly efficient, tin( ii )/PMHS catalyzed reductive N -alkylation of arylamines with ketones affording tertiary arylamines. A very wide substrate scope was observed for the current catalytic method as all six permutations of ketones/aldehydes/heterocyclic carbonyls and primary/secondary/heterocyclic amines were well tolerated, enabling access to secondary, tertiary and heterocyclic amines. The method is also convenient for the synthesis of N -substituted isoindolinones and phthalazinones via a tandem amination–amidation sequence. Mechanistic investigations revealed a carbocationic pathway instead of an ordinary direct reductive amination pathway.
Onkar S. Nayal; Maheshwar S. Thakur; Vinod Bhatt; Upendra Sharma; Manoranjan Kumar; Bikram Singh. Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-alkylation of secondary amines with ketones through an alternative pathway. Chemical Communications 2016, 52, 9648 -9651.
AMA StyleOnkar S. Nayal, Maheshwar S. Thakur, Vinod Bhatt, Upendra Sharma, Manoranjan Kumar, Bikram Singh. Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-alkylation of secondary amines with ketones through an alternative pathway. Chemical Communications. 2016; 52 (62):9648-9651.
Chicago/Turabian StyleOnkar S. Nayal; Maheshwar S. Thakur; Vinod Bhatt; Upendra Sharma; Manoranjan Kumar; Bikram Singh. 2016. "Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-alkylation of secondary amines with ketones through an alternative pathway." Chemical Communications 52, no. 62: 9648-9651.
Rohit Arora; Sakshi Bhushan; Rakesh Kumar; Rahul Mannan; Pardeep Kaur; Bikram Singh; Ritika Sharma; Adarsh Pal Vig; Balbir Singh; Amrit Pal Singh; Saroj Arora. To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations. Anti-Cancer Agents in Medicinal Chemistry 2016, 1 .
AMA StyleRohit Arora, Sakshi Bhushan, Rakesh Kumar, Rahul Mannan, Pardeep Kaur, Bikram Singh, Ritika Sharma, Adarsh Pal Vig, Balbir Singh, Amrit Pal Singh, Saroj Arora. To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations. Anti-Cancer Agents in Medicinal Chemistry. 2016; ():1.
Chicago/Turabian StyleRohit Arora; Sakshi Bhushan; Rakesh Kumar; Rahul Mannan; Pardeep Kaur; Bikram Singh; Ritika Sharma; Adarsh Pal Vig; Balbir Singh; Amrit Pal Singh; Saroj Arora. 2016. "To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations." Anti-Cancer Agents in Medicinal Chemistry , no. : 1.
Dinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Ahuja. Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques. Combinatorial Chemistry & High Throughput Screening 2016, 19, 1 -1.
AMA StyleDinesh Kumar, Rakesh Kumar, Bikram Singh, Paramvir Ahuja. Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques. Combinatorial Chemistry & High Throughput Screening. 2016; 19 (999):1-1.
Chicago/Turabian StyleDinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Ahuja. 2016. "Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques." Combinatorial Chemistry & High Throughput Screening 19, no. 999: 1-1.
Dinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Singh Ahuja. Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques. Combinatorial Chemistry & High Throughput Screening 2016, 19, 1 .
AMA StyleDinesh Kumar, Rakesh Kumar, Bikram Singh, Paramvir Singh Ahuja. Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques. Combinatorial Chemistry & High Throughput Screening. 2016; 19 (3):1.
Chicago/Turabian StyleDinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Singh Ahuja. 2016. "Comprehensive Chemical Profiling of Picrorhiza kurroa Royle ex Benth Using NMR, HPTLC and LC-MS/MS Techniques." Combinatorial Chemistry & High Throughput Screening 19, no. 3: 1.
Eight compounds have been isolated and characterized belonging to different classes. The pharmacological evaluation of extract, fractions and pure molecules revealed the ethnomedicinal value of T. cordifolia for anticancer and immunomodulatory activities.
Manju Bala; Kunal Pratap; Praveen Kumar Verma; Bikram Singh; Yogendra Padwad. Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. Journal of Ethnopharmacology 2015, 175, 131 -137.
AMA StyleManju Bala, Kunal Pratap, Praveen Kumar Verma, Bikram Singh, Yogendra Padwad. Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC. Journal of Ethnopharmacology. 2015; 175 ():131-137.
Chicago/Turabian StyleManju Bala; Kunal Pratap; Praveen Kumar Verma; Bikram Singh; Yogendra Padwad. 2015. "Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC." Journal of Ethnopharmacology 175, no. : 131-137.
Silylation of hydrocarbons is one of the most important transformations due to the diverse application of organosilanes. Continuous progress is being made in organosilane synthesis particularly through direct C–H activation/functionalization. This minireview compiles various processes reported for C–Si bond formation from 2000–2014, through C–H activation/functionalization (proximal and remote) and metal-free approaches. 1 Introduction 2 C–Si Bond Formation through C–H Activation in Intermolecular Fashion 2.1 C–Si Bond Formation through Direct C(sp2)–H Activation 2.2 C–Si Bond Formation through Directing Group Assisted C(sp2)–H Activation 2.3 C–Si Bond Formation through sp3 C–H Activation 3 C–Si Bond Formation through Proximal C–H Activation/Functionalization in Intramolecular Fashion 3.1 Intramolecular C–Si Bond Formation through C(sp2)–H Activation 3.2 Intramolecular C–Si Bond Formation through C(sp3)–H Activation 4 Siloles Synthesis through Heteroannulation 5 C–Si Bond Formation through Remote C–H Activation 6 C–Si Bond Formation through C–O Bond Cleavage 7 Metal-Free Methods for C–Si Bond Formation 8 Summary and Outlook
Upendra Sharma; Ritika Sharma; Rakesh Kumar; Inder Kumar; Bikram Singh. Selective C–Si Bond Formation through C–H Functionalization. Synthesis 2015, 47, 2347 -2366.
AMA StyleUpendra Sharma, Ritika Sharma, Rakesh Kumar, Inder Kumar, Bikram Singh. Selective C–Si Bond Formation through C–H Functionalization. Synthesis. 2015; 47 (16):2347-2366.
Chicago/Turabian StyleUpendra Sharma; Ritika Sharma; Rakesh Kumar; Inder Kumar; Bikram Singh. 2015. "Selective C–Si Bond Formation through C–H Functionalization." Synthesis 47, no. 16: 2347-2366.
Manju Bala; Praveen Kumar Verma; Neeraj Kumar; Bikram Singh. ChemInform Abstract: Direct Waste-Free Synthesis of Amides from Nonactivated Carboxylic Acids and Amines: Application to the Synthesis of Tetrahydroisoquinolines. ChemInform 2015, 46, 1 .
AMA StyleManju Bala, Praveen Kumar Verma, Neeraj Kumar, Bikram Singh. ChemInform Abstract: Direct Waste-Free Synthesis of Amides from Nonactivated Carboxylic Acids and Amines: Application to the Synthesis of Tetrahydroisoquinolines. ChemInform. 2015; 46 (26):1.
Chicago/Turabian StyleManju Bala; Praveen Kumar Verma; Neeraj Kumar; Bikram Singh. 2015. "ChemInform Abstract: Direct Waste-Free Synthesis of Amides from Nonactivated Carboxylic Acids and Amines: Application to the Synthesis of Tetrahydroisoquinolines." ChemInform 46, no. 26: 1.
Dinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Singh Ahuja. Reproducible reversed-phase high-performance thin-layer chromatography-based quality-control method for the endangered medicinal plantPicrorhiza kurroaRoyle ex Benth. JPC – Journal of Planar Chromatography – Modern TLC 2015, 28, 256 -261.
AMA StyleDinesh Kumar, Rakesh Kumar, Bikram Singh, Paramvir Singh Ahuja. Reproducible reversed-phase high-performance thin-layer chromatography-based quality-control method for the endangered medicinal plantPicrorhiza kurroaRoyle ex Benth. JPC – Journal of Planar Chromatography – Modern TLC. 2015; 28 (3):256-261.
Chicago/Turabian StyleDinesh Kumar; Rakesh Kumar; Bikram Singh; Paramvir Singh Ahuja. 2015. "Reproducible reversed-phase high-performance thin-layer chromatography-based quality-control method for the endangered medicinal plantPicrorhiza kurroaRoyle ex Benth." JPC – Journal of Planar Chromatography – Modern TLC 28, no. 3: 256-261.
An efficient water-catalyzed method has been developed for the synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles in one step. The present method excludes the usage of toxic metal catalysts and bases to produce benzazoles in good to excellent yields. An efficient and versatile water-mediated method has been established for the synthesis of various 2-arylbenzazoles. The present protocol excludes the usage of any catalyst and additive provided excellent selectivities and yields with high functional group tolerance for the synthesis of 2-arylated benzimidazoles, benzoxazoles, and benzothiazoles. Benzazolones were also synthesized using similar reaction protocol.
Manju Bala; Praveen Kumar Verma; Deepika Sharma; Neeraj Kumar; Bikram Singh. Highly efficient water-mediated approach to access benzazoles: metal catalyst and base-free synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles. Molecular Diversity 2015, 19, 263 -272.
AMA StyleManju Bala, Praveen Kumar Verma, Deepika Sharma, Neeraj Kumar, Bikram Singh. Highly efficient water-mediated approach to access benzazoles: metal catalyst and base-free synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles. Molecular Diversity. 2015; 19 (2):263-272.
Chicago/Turabian StyleManju Bala; Praveen Kumar Verma; Deepika Sharma; Neeraj Kumar; Bikram Singh. 2015. "Highly efficient water-mediated approach to access benzazoles: metal catalyst and base-free synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles." Molecular Diversity 19, no. 2: 263-272.