Energy savings and seismic risk mitigation are the main issues regarding the refurbishment of traditional buildings. Referring to historic buildings, we have to take into account, as design requirements, the cultural sustainability, which means the respects of the cultural value of the built heritage. Therefore, for historic buildings is not acceptable to adopt the conventional design choices applied to newer buildings on energy efficiency and seismic risk mitigation. Generally, the design on the built heritage requires a careful cognitive phase for firstly to identify the performance deficits and subsequently to define which actions are compatible with the cultural value of each building, according to a “case by case” approach. In Italy, specific guidelines have been elaborated on cultural heritage but such guidelines are not integrated into a single methodological process. This paper, through the study of two historic buildings, aims to identify the relationship between the two specialisms, seismic and energy, within an integrated approach. As a result, this study proposes an innovation process characterized by the integration of these two protocols within the cognitive phase and, especially in the pre-diagnosis phase; this phase is identified in the standard diagnosis (Energy approach) and in the LV2 knowledge (Seismic empirical approach).