This study addresses the trajectory tracking control challenges of robot manipulators with uncertain dynamics. The aim is to achieve precise and smooth trajectory regulation through a novel composite position predictive control (PPC) scheme that integrates motion profile and disturbance preview techniques. First, we perform offline dynamics identification and feedforward compensation alongside a pre-defined motion profile. To handle the disturbances arising from uncertain dynamics, a super-twisting disturbance observer is designed, resulting in a dynamically compensated prediction model. Furthermore, the receding optimization operations for PPC are executed by solving an optimal solution associated with a joint angle tracking error. The combination of feedforward and feedback control improves the robot manipulator’s absolute positioning accuracy as opposed to the conventional model predictive control method, especially when dealing with uncertain dynamics. The effectiveness of the proposed control method is confirmed through trajectory tracking experiments conducted on a six-degree-of-freedom robot platform with varying end-effector loads. The experimental results demonstrate that the proposed PPC method enhances tracking accuracy by approximately 45% and 25% when compared to the traditional inverse dynamic control (IDC) and the robust IDC approaches, respectively.