OBJECTIVE: Although systemic lupus erythematosus of varying severity has been seen in our clinics, there is no information regarding the prevalence of the disease among Saudi nationals. We conducted this study to determine the prevalence of systemic lupus erythematosus in Al-Qaseem region of the Kingdom of Saudi Arabia. METHODS: A community survey of towns and villages in the Al-Qaseem area of central Saudi Arabia was conducted in 3 phases to determine the prevalence of systemic lupus erythematosus in the region. RESULTS: Of the 10,372 studied, 2 cases of systemic lupus erythematosus were identified using the criteria set for the diagnosis of systemic lupus erythematosus by the American College of Rheumatology. Based on that, the prevalence of systemic lupus erythematosus was estimated to be 19.28 per 100,000 population in the region. CONCLUSION: The estimated prevalence of systemic lupus erythematosus in Al-Qaseem area is similar to that found in western countries.

OBJECTIVE: The aim of this study was to estimate the prevalence of clinical osteoarthritis (OA) of the knee in Al-Qaseem, a central province in the Kingdom of Saudi Arabia (KSA). METHODS: A house to house survey of randomly selected inhabitants of Al-Qaseem, KSA was conducted. A total of 10,406 persons were interviewed of whom 5,894 were above the age of 16 years. The study was carried out at King Khalid University Hospital and College of Medicine, Riyadh, KSA, from September 1993 to February 1995. They were questioned regarding musculoskeletal complaints, and those positively identified were interviewed further by a team of trained medical staff and later examined by trained doctors including rheumatologists. RESULTS: We found 766 (13%) cases of clinical OA of the knee in the 5,894 adult population (13%). The prevalence of OA increased with increasing age reaching 30.8% in those aged 46-55 years and 60.6% in the age group 66-75 years. The odds ratio (OR) for the association between clinical OA of the knee and age adjusted for sex and body mass index (BMI) was 1.0894 (95% CI, 1.08-1.09). The association of clinical OA of the knee with female sex was also significant [OR (adjused for age and BMI) was 1.261 (95% CI, 1.0456-1.5208)]. CONCLUSION: Clinical OA of the knee is common in this community, particularly in the older age groups.

OBJECTIVE: To find out the relationship between radiographic osteoarthritis (OA) of the knee, generalized OA and serum cholesterol. METHODS: Over a period of 7 months from September 1998 through to March 1999, 246 patients attending 14 primary care clinics in Northern Riyadh, Kingdom of Saudi Arabia, for different non-musculoskeletal complaints were recruited in the study. Their knees, hands and wrists were radiographed. Their ages, sex, weight, height, body mass index (BMI), fasting serum cholesterol, triglycerides and uric acid were recorded. RESULTS: There were 113 females and 133 males with average ages 46 ± 14.2 and 51.54 ± 16.0 years. One hundred and twenty-two (49.6%) cases of knee OA and 58 (23.6%) cases of generalized OA were found and analyzed for the association with serum cholesterol levels. Crude odds ratio (OR) for the relationship between knee OA and the third tertile of serum cholesterol was 2.33 (95% CI, 1.19-4.58) which on adjusting for age, sex, BMI, serum uric acid and triglycerides were 2.68 (95% CI, 2.00-3.64). For generalized OA, the crude odds ratio (OR) in relation to the third tertile of serum cholesterol was 1.65 (95% CI, 0.78-3.53), adjusted OR was 2.18 (95% CI, 1.55-3.15). CONCLUSION: The results showed an association between high serum cholesterol level and both knee and generalized OA.