Breast cancer is the most common and the leading cause of cancer death in women worldwide; treating invasive breast carcinomas is challenging due to the side effects of chemotherapeutics. Compounds isolated from natural sources have been proposed as potential molecules for cancer therapy; for instance, the homoisoflavonoid brazilin has shown pharmacological properties, including anti-tumoral and anti-inflammatory activities. In this study, we isolated brazilin from the heartwood of Haematoxylum brasiletto; then, we performed a semi-synthesis by adding three methyl or acetyl groups to the core structure of brazilin. We confirmed the identity of brazilin and its derivatives by spectroscopic data (¹H NMR and ¹³C NMR) and measured their purity by optical rotation. Then, we analyzed the effects of brazilin and its derivatives in three mammary gland-derived cell lines: the TNBC MDA-MB-231, the ERα(+) MCF7, and the non-tumorigenic MCF10A. We evaluated the cell viability by MTT assays, cell migration by wound-healing assays, and focal adhesion kinase (FAK) activation by Western blot. Regarding biological assays, the MTT assay showed that these compounds showed cytotoxic effects on the MCF7 and MDA-MB-231 breast cancer cells at 20 µM but was not toxic in non-tumorigenic MCF10A mammary epithelial cells. Specifically, the greatest effects found from treatment with the compounds were in the MDA-MB-231 cell line, where the IC50 of brazilin was 49.92 μM, and for MCF7, the brazilin-(OAc)₃ was 49.97 μM. These effects were dose- and time-dependent, as well as being associated with a decrease in the levels of cell migration and FAK activation.

Honey is mainly composed of glucose and fructose between 80 and 85 %, which come from the nectar collected by the bees; therefore, it is considered a great caloric source. The present study aimed to evaluate the influence of color, on chemical composition and bioactive properties of polyfloral honey collected in different geographical regions of Guerrero state, Mexico. The honey samples were from the 2018 harvest and honeys were analyzed to determine their total phenolic and flavonoids content, as well as their antioxidant and antimicrobial activity. The phenolic and flavonoids content varied considerably, and the highest values were obtained for dark amber honeys. Similarly, dark amber honeys showed higher antioxidant activity. The antibacterial activity was more effective against Gram-positive bacteria than Gram-negative bacteria; also, results indicated that fungi were less susceptible than bacteria. A positive correlation between color and antioxidant capacity was found. Correlation existed also between color vs phenolics content, vs flavonoid content or between phenolic vs flavonoid. Principal component analysis (PCA) on bioactive results was a useful tool to characterize different types of honey based on the variables of each group in relation to the similarity between the samples.

El uso extensivo de agroquímicos para incrementar la producción de alimentos en la actualidad, ha conllevado a la perdida de fertilidad del suelo, bajo rendimiento en los cultivos, perdida de ganancias para los agricultores entre muchos otros factores negativos, las bacterias promotoras de crecimiento vegetal se han empleado para incrementar la producción de cultivos de interés agrícola, disminuyendo el uso de químicos y creando una agricultura sostenible. El objetivo de este trabajo fue evaluar dos consorcios de bacterias caracterizadas como BPCV, en cultivos de lechuga. El cultivo de lechuga orejona se realizó directamente en una parcela demostrativa, en todo el proceso se acompañó del agricultor, las semillas se desinfectaron previamente, se embebieron por los consorcios empleados y se hicieron germinar en pachol directamente en el suelo, después las plántulas se colocaron en surcos para darles seguimiento. Obteniendo lechugas de mayor tamaño y biomasa con el consorcio B que consta de B. licheniformis, P. putida, Pseudomonas sp., E. cloacae y A. vinelandii con un valor de p< 0.05. Por lo que se propone como estrategia para incrementar la producción de Lactuca sativa L., en las comunidades dedicadas a este cultivo, mejorando el rendimiento de producción, mayores ganancias económicas y ambientalmente sostenibles.

Guerrero is one of the least studied states in Mexico for Fungi, despite its great diversity of vascular plants. The aim of this work was to update previously reported genera, provide new records from Guerrero and discuss the biocultural significance and potential use of Boletales from Guerrero, Mexico. Astraeus morganii Phosri, Watling & M.P. Martín is recorded for the first time in Mexico. Sixty‑eight species of Boletales reported from Guerrero with an annotated checklist, which includes photographs; 34 species are newly recorded from Guerrero. The family Boletaceae is the most diverse followed by Suillaceae and Scleroderma taceae. Aureoboletus russellii (Frost) G. Wu & Zhu L. Yang, Aureoboletus readii Ayala‑Vásquez, Pérez‑Moreno, Martínez‑Reyes, Carbajal‑Ramírez, Hygrophoropsis aurantiaca (Wulfen) Maire ex Martin‑Sans, Scleroderma texense Berk., and Tylopilus tabacinus (Peck) Singer are reported as having biocultural importance to Nahuatl, Na Savi, and Me’phaa native cultures. In addition, 45 species of Boletales are reported as potentially edible.

La hidroponía es una técnica de cultivo de plantas sin utilizar tierra, en su lugar se utiliza una solución de nutrientes y agua para proporcionar los nutrientes necesarios para el crecimiento de las plantas. Esta técnica de cultivo ha ganado popularidad en los últimos años debido a su alta eficiencia en el uso del agua, la falta de necesidad de tierra y la capacidad para producir cultivos durante todo el año en cualquier ubicación. Gracias a ello se tiene contemplado para la elaboracion de una alternativa agrícola que pueda fortalecer seguridad alimentaria en la población indígena y afromexicana de Tepoxtiapan, Chilpancingo, Guerrero. El objetivo es beneficiar a las familias de la comunidad para que dispongan de una alternativa de producción agrícola para mejorar sus condiciones de alimentación, nutrición y fuentes de ingreso, basados en la gestión y autogestión de cultivos hidropónicos. Para el diseño de la propuesta para los habitantes de la comunidad, Con base al material bibliográfico se expone los diversos sistemas hidropónicos demostrando las ventajas y desventajas para la comunidad haciendo énfasis en cuanto a costo de inversión inicial, insumos, beneficios de producción.