Background/Objectives: Mesh repair reduces hernia recurrence compared with suture repair, but permanent synthetic meshes are associated with chronic foreign-body complications. Biosynthetic poly-4-hydroxybutyrate mesh (Phasix™) provides temporary reinforcement with gradual resorption; however, short-term real-world outcomes across different hernia types remain limited. This study evaluated short-term outcomes after Phasix™ hernia repair and identified factors associated with baseline recurrent hernia at presentation. Methods: This retrospective cohort included patients ≥ 16 years who underwent open or laparoscopic hernia repair with Phasix™ at King Abdulaziz Medical City (2020–2023). Patients receiving other mesh types were excluded. Demographic, operative, and postoperative data were analyzed. Multivariable logistic regression identified factors associated with baseline recurrent hernia. Results: Among the 228 patients (51.8% female; mean age 55 years), hernia types were incisional (36.0%), paraumbilical (26.3%), and inguinal (24.6%). Early complications were uncommon: seroma in 2.2% and surgical site infection in 1.8% at 1 month. One-year recurrence occurred in 1.3% (3/228). Female sex, prior incisional hernia repair, previous mesh removal, and open repair independently predicted baseline recurrent hernia, while laparoscopic repair was protective. Conclusions: Phasix™ repair demonstrated low short-term complication rates and rare 1-year recurrence across ventral and inguinal hernias. Short-term outcomes were driven mainly by patient and procedural factors rather than mesh-specific effects.

Rotator cuff injuries (RCIs) are common and debilitating injuries, particularly among older adults. Surgical repair, such as arthroscopic rotator cuff repair (RCR), is the preferred treatment, with pre-operative risk factors, including vitamin D deficiency, associated with poor outcomes, but the relationship between vitamin D deficiency and outcomes following RCR remains uncertain. The purpose of this meta-analysis was to investigate the relation between pre-operative vitamin D deficiency and post-operative outcomes following RCR. A systematic review and meta-analysis were conducted to explore the association including randomized clinical trials, observational studies, and case-series with more than 10 adult participants (age > 18) evaluating post-operative outcomes in vitamin D-deficient RCR patients. Six studies encompassing 44,546 patients with RCIs were included. Vitamin D deficiency was significantly associated with an increased risk of surgery revision (RR 1.220; 95% CI 1.133, 5.245; p < .001). However, there was no significant correlation between vitamin D deficiency and post-operative pain (p = .064), tear size (p = .480), or functional scores, including ASES (p = .820), Constant score (p = .365), and UCLA score (p = .780). This study revealed that vitamin D deficiency increased the risk of surgery revision to address repair failure following RCR by 22% in vitamin D-deficient patients. No significant associations were found with post-operative pain, which could be related to the limited number of studies. Further studies are still needed to yield more conclusive results.