Novel therapies are required due to the rising cancer burden. Conventional chemotherapeutics tend to be particularly toxic, but there is a promising alternative for oncogenes, such as c-MYC. Often overexpressed in many cancer types, the potential c-MYC oncogene seems essential to the development of cancer. Targeting c-MYC protein directly was limited, but these DNA structures composed of guanine-rich sequences suppress c-MYC transcription. This review discusses recent advances in developing small compounds that selectively bind to and stabilize c-MYC G-quadruplexes (G4). These molecules have also shown promise for the inhibition of c-MYC signaling and inhibition of tumor growth, suggesting that G-quadruplex targeting could be a promising therapeutic for cancer.

Neurodegenerative diseases involve gradual breakdown and eventually death of nerve cells. Neurodegenerative disorders lack an effective therapy because the central nervous system's neurons have a limited capacity for regeneration. There are many different causes of neurological illnesses, such as congenital anomalies, genetic disorders, autoimmune diseases, infections, and environmental or lifestyle-related health issues. Endophytes are a group of microorganisms that thrive within host plants without apparently harming them. Both plant-based bioactives and fungal endophyte-based bioactives exhibit neuroprotective activities. Antioxidant activity, anti-amyloid aggregation, anti-inflammatory, monoamine modification, and inhibition of acetylcholinesterase are some of the mechanisms by which plant-based bioactives exhibit neuroprotective activities. Ongoing research focuses on the neuroblastic cell regeneration approach to treat neurodegenerative disorders. Peptides, cytokines, and polyphenolic antioxidants have regenerative capacity and thus can be used to treat neurodegenerative diseases. Over 60 million people suffer from these incurable diseases worldwide as a result of the rapidly aging society. As a result, finding novel medications and therapeutic approaches has become a crucial study area. This chapter focuses on the efficacy of natural compounds derived from plants and associated microbes towards neurodegenerative disorders. <!----> <!----> <!----> <!---->

Introduction and aim. Wound healing is a biological process that aims to restore tissue integrity and function. Despite medical advances, wound management remains challenging. Traditional medicinal preparations, like Apamarga ksharodaka (AK), offer promising therapeutic potential due to their phytochemical richness. This study evaluated wound healing and antimicrobial activity of AK. This study aimed to validate the traditional claim of AK’s wound healing potential using an excision wound model. Material and methods. An excision wound model was created using 24 male Wistar rats. A positive control group applied 5% w/w povidone-iodine (PI) ointment. Wound contraction (WC), epithelialization period (ET), wound closure day, and histopathology were assessed. Antibacterial activity was evaluated against Escherichia coli, Streptococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results. AK showed slightly better wound healing than PI ointment, with significant results in WC rate, wound closure, and ET. Histopathology revealed normal skin and organ architecture. The minimum MIC was 6.25 mg/ml against Pseudomonas aeruginosa with a maximum inhibition zone of 15 mm. Conclusion. AK is safe and effective for wound healing.