Polymers are composed of many smaller units connected by covalent bonds, with higher molecular weight and larger molecular structure. Due to their economical efficiency and easy modification, researchers have discovered the potential of polymers as the flotation reagent in mineral processing, including the roles of depressant, flocculant, and frother. This paper provides a comprehensive review of the utilization of polymers in mineral flotation, emphasizing their current applications and mechanistic investigations. The study categorizes polymers into three types: natural polymers, modified polymers, and synthesized polymers. Detailed discussions include the polymers structures, functional properties, adsorption mechanisms and specific application examples of each reagent are shown in the main text, which will provide a vital reference for the development of highly efficient and environmentally friendly reagents in mineral flotation.