Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a special classification of indolent kidney tumors newly discovered in recent years. It is extremely uncommon, with only a few clinical and pathological reports, and its imaging description are very rare. Here, we present a case of ESC RCC.

To develop and evaluate a intralesional and perilesional radiomics strategy based on different machine learning model to differentiate International Society of Urological Pathology (ISUP) grade > 2 group and ISUP ≤ 2 prostate cancers (PCa). 340 case of PCa patients confirmed by radical prostatectomy pathology were obtained from two hospitals. The patients were divided into training, internal validation, and external validation groups. Radiomic features were extracted from T2-weighted imaging, and four distinct radiomic feature models were constructed: intralesional, perilesional, combined tumoral and perilesional, and intralesional and perilesional image fusion. Four machine learning classifiers logistic regression (LR), random forest (RF), extra trees (ET), and multilayer perceptron (MLP) were employed for model training and evaluation to select the optimal model. The performance of each model was assessed by calculating the area under the ROC curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score. The AUCs for the RF classifier were higher than that of LR, ET, and MLP, and was selected as the final radiomic model. The nomogram model integrating perilesional, combined intralesional and perilesional, and intralesional and perilesional image fusion had an AUC of 0.929, 0.734, 0.743 for the training, internal, and external validation cohorts, respectively, which was higher than that of the individual intralesional, perilesional, combined intralesional and perilesional, and intralesional and perilesional image fusion models. The proposed nomogram established from perilesional, combined intralesional and perilesional, and intralesional and perilesional image fusion radiomic has the potential to predict the differentiation degree of ISUP PCa patients. Not applicable.