The data explosion driven by advancements in genomic research, such as high-throughput sequencing techniques, is constantly challenging conventional methods used in genomics. In parallel with the urgent demand for robust algorithms, deep learning has succeeded in various fields such as vision, speech, and text processing. Yet genomics entails unique challenges to deep learning, since we expect a superhuman intelligence that explores beyond our knowledge to interpret the genome from deep learning. A powerful deep learning model should rely on the insightful utilization of task-specific knowledge. In this paper, we briefly discuss the strengths of different deep learning models from a genomic perspective so as to fit each particular task with proper deep learning-based architecture, and we remark on practical considerations of developing deep learning architectures for genomics. We also provide a concise review of deep learning applications in various aspects of genomic research and point out current challenges and potential research directions for future genomics applications. We believe the collaborative use of ever-growing diverse data and the fast iteration of deep learning models will continue to contribute to the future of genomics.

The complex entanglement between darkness and noise hinders the advance of low-light image enhancement. Most existing methods adopted lightening-then-denoising or embedded a special denoising module into enhancement network without specific noise knowledge as supervision to restore low-light images. However, they either fail to remove the amplified noise or blur the detail information. Against above drawbacks, we propose a novel dual prior guidance method for low-light image enhancement that relights darkness and suppresses noise simultaneously. Concretely, the main novelties of our proposed method are three-fold. Firstly, our formulation originates from a statistic observation that darkness can be disentangled into luminance channel, yet noise still exists each channel when low-light images are transformed from RGB space to YCbCr space. It inspires us to design an ingenious method, extracting noise and darkness, termed END, to enhance low-light images. Secondly, we propose a prior extraction network with prior composition module to extract luminance and noise priors from different channels. Thirdly, an image enhancement network deployed with prior guidance module is proposed to progressively lighten the darkness and remove noise. Extensive experiments on multiple benchmarks demonstrate that our proposed method achieves remarkable performance compared to other state-of-the-art low-light image enhancement methods. The source code and trained model can be found in https://github.com/WHK-Huake/END.

High-resolution networks have made significant progress in dense prediction tasks such as human pose estimation and semantic segmentation. To better explore this high-resolution mechanism on mobile devices, Lite-HRNet incorporates shuffle operations to reduce computational complexity in the channel dimension, while Dite-HRNet employs dynamic convolution and pooling to capture long-range interactions with low computational complexity in the spatial dimension. The core idea behind both approaches is to efficiently capture information in either the channel or spatial dimension. However, shuffle operations and dynamic operations are not hardware-friendly. As a result, both Lite-HRNet and Dite-HRNet cannot achieve the desired inference speed on specialized devices, including Neural Processing Units (NPUs) and Graphics Processing Units (GPUs). To overcome these limitations, we present a simple Hardware-Friendly Lightweight High-resolution Network (HF-HRNet) based on our proposed Hardware-Friendly Uniform-sized Mug (HUM) block. HUM block mainly consists of the Cascaded Depthwise (CAD) block and Multi-Scale Context Embedding (MCE) block. The CAD block cascades depthwise convolutions to obtain a larger receptive field in the spatial dimension, while the MCE block aggregates multi-scale spatial feature information from different scales and adjusts channel features. Extensive experiments are conducted on human pose estimation (COCO, MPII) and semantic segmentation (Cityscapes), resulting in a better trade-off between inference speed and accuracy on both NPUs and GPUs. It is noteworthy that on the COCO test-dev set, HF-HRNet-30 outperforms Dite-HRNet-30 and Lite-HRNet-30 by 1.9 AP and 2.8 AP, respectively, while running about 13 times faster and 9 times faster on NPUs, respectively. Our code are publicly available for use: https://github.com/zhanghao5201/HF-HRNet.

Sequential recommendations aim to predict the user’s next behaviors items based on their successive historical behaviors sequence. It has been widely applied in lots of online services. However, current sequential recommendations use the adjacent behaviors to capture the features of the sequence, ignoring the features among nonadjacent sequential items and the summarized features of the sequence. To address the above problems, in this paper, we propose an annular-graph attention based sequential recommendation (AGSR) model by exploring user’s long-term and short-term preferences for the personalized sequential recommendation. For user’s short-term preferences, AGSR builds an annular-graph on the sequence of user behavior. Then, AGSR proposes an annular-graph attention applying on the sub annular-graph to explore local features and applying annular-graph attention on entire annular-graph to explore the global features and the skip features. For user’s long-term preferences, the latent factor model are introduced in AGSR. The experimental results on two public datasets show that our model outperforms the state-of-the-art methods.