In a series of publications, we attempt to demonstrate the prophylactic role of bromhexine hydrochloride (BHH) and the curative role of high colchicine doses against COVID-19. Effects of long-term prophylaxis with BHH are presented in two cases of elderly women with severe comorbidity. After long-term prophylactic use of BHH from 3 to 6 months, one does not get sick from COVID-19, and the other passes it almost asymptomatically, even though all their family members fall ill. The dramatic healing effect of colchicine was demonstrated in a family in which both spouses became ill with COVID-19 almost simultaneously. They are treated in different hospitals, and where colchicine is administered in high doses, the patient recovered. The other patient developed complications and died on standard treatment without high doses of colchicine. An outpatient accidentally overdosed on colchicine (12.5mg). The therapy was stopped immediately. Clinically, on the third day, there are absolutely no symptoms. These cases reaffirm the prophylactic effect of BRH and the curative effect of high-dose colchicine

Objective: Retrospective analysis of results from open posterior synovectomy for TGCT of knee joint Material and method: The surgery technique includes an approach to retrocondylar space with retraction of m. gastrocnemius, posterior capsulotomy and synovectomy with direct visual control. This approach allows protection of popliteal neurovascular bundle and total neoplasm removal. The study presents 13 cases from different age groups with treatment for 4 D-TGCT and 9-N-TGCT, which localization is in posterior knee compartment. Cases are from period June 2010-December 2024 Results: Mean follow-up time in children is 13.67±1.53 months (min - 8 months) and in adults is 49.3±58.39 months (9 months-11 years). Range of motion had been fully restored for 3 months in 9 cases and for the rest - until 10th postsurgical month. There are not any repeatable monoarthritis and neoplasm relapse in 90% of cases according to control MRI . There are 2 cases with marked relapse, followed by reopetarion because of incorrect planning of primary treatment. Conclusions: : This surgical technique gives opportunity for fully removal of TGCT with intraarticular retrocondylar localization. Anatomical synovectomy is performed, while using direct visual control with opportunity for protection of poplitel artery and nerves, localized in popliteal fossa.