Background/Objectives: The rising global prevalence of metabolic diseases (e.g., obesity, type 2 diabetes mellitus) underscores the need for effective interventions. Omega-3 polyunsaturated fatty acids (PUFAs) exhibit therapeutic potential, yet their molecular mechanisms remain unclear. This systematic review synthesizes a decade (2014–2024) of omics research to elucidate Omega-3 PUFA mechanisms in metabolic diseases and identify future directions. Methods: A PRISMA-guided search of the Web of Science identified studies on Omega-3 PUFAs, metabolic diseases, and omics. After excluding reviews, non-English articles, and irrelevant studies, 72 articles were analyzed (16 multi-omics, 17 lipidomics, 10 transcriptomics/metabolomics/microbiomics each, and 6 proteomics). Results: Omics studies demonstrated that Omega-3 PUFAs, particularly EPA and DHA, improve metabolic health through interconnected mechanisms. They regulate epigenetic processes, including DNA methylation and miRNA expression, influencing genes linked to inflammation and insulin sensitivity. Omega-3 PUFAs reduce oxidative stress by mitigating protein carbonylation and enhancing antioxidant defenses. Gut microbiota modulation is evident through increased beneficial taxa (e.g., Bacteroidetes, Akkermansia) and reduced pro-inflammatory species, correlating with improved metabolic parameters. Mitochondrial function is enhanced via upregulated fatty acid oxidation and TCA cycle activity, while anti-inflammatory effects arise from NF-κB pathway suppression and macrophage polarization toward an M2 phenotype. Challenges include interindividual variability in responses and a limited understanding of dynamic metabolic interactions. Conclusions: Omega-3 PUFAs target multiple pathways to improve metabolic health. Future research should prioritize chemoproteomics for direct target identification, multi-omics integration, and personalized strategies combining Omega-3 with therapies like calorie restriction.

As an agri-food by-product, the rice bran of pigmented rice, encompassing varieties such as red, black, and purple rice, has garnered increasing attention due to its richness in terms of bioactive compounds. Being mainly composed of the pericarp, aleuron, seed coat, and germ, the brown outer layer of the rice kernel offers potential health benefits and has applications in skincare. Human skin serves as the primary barrier against external threats, including pathogens, pollutants, and ultraviolet (UV) radiation. Notably, UV radiation accelerates the aging process and contributes to various skin issues. Recent trends suggest a heightened interest in incorporating pigmented rice into skincare regimens, motivated by its potential to mitigate oxidative stress, inflammation, and pigmentation, which are pivotal factors in skin aging and photodamage. With increasing consumer demand for natural and sustainable ingredients, pigmented rice has emerged as a promising candidate within the skincare and personal care sectors, effectively bridging the gap between nutrition and dermatological health. This review examines the applications of pigmented rice in skincare, with a particular focus on its bioactive components and potential mechanisms of action that contribute to skin health. The unique chemical composition of pigmented rice, which includes compounds such as anthocyanins, flavonoids, phenolic acids, and vitamin E, underlies its antioxidant, anti-inflammatory, and skin-protective properties. Despite the increasing recognition of its benefits, a comprehensive understanding of the underlying mechanisms remains limited, underscoring the necessity for further research to exploit the potential of pigmented rice in skincare applications fully.

Background: Comprehensive exploration of lip aging remains limited due to anatomical complexity of the structure, with current investigations predominantly focusing on aspects such as dryness management, cheilitis prevention and treatment, and surgical lifts.Aims: This article aims to review multiple aspects of lip aging and to explore anti‐aging approaches for the lips, thereby providing actionable insights for the development of cosmetic lip care products.Methods: We conducted a literature search in the PubMed database using keywords related to lip aging, and selected the most relevant articles for in‐depth reading, summarization, and integration to form the content of this review.Results: Due to the significant differences between lip and facial skin in terms of barrier function, melanin content, transepidermal absorption capacity, physiological activity frequency, and fat distribution, the aging characteristics of lips also exhibit uniqueness. At the same time, there are gender differences in lip aging manifestations, with women typically showing more noticeable perioral wrinkles compared to men.Conclusions: The clinical manifestations and pathogenic mechanisms of lip aging differ significantly from those of facial aging, requiring distinct priorities in anti‐aging product development. For the vermilion, the focus should be on barrier restoration, mild anti‐aging approaches, and photoaging prevention. In contrast, perioral anti‐aging may be addressed by inhibiting ECM degradation and enhancing tissue volume. Addressing gender differences can guide the development of anti‐aging lip products tailored to women, while managing associated pigmentary changes offers a unique avenue for this purpose.

Deep learning-based drug-target interaction (DTI) prediction methods have demonstrated strong performance; however, real-world applicability remains constrained by limited data diversity and modeling complexity. To address these challenges, we propose SCOPE-DTI, a unified framework combining a large-scale, balanced semi-inductive human DTI dataset with advanced deep learning modeling. SCOPE-DTI is constructed from 13 public repositories and expands data volume by up to 100-fold compared to common benchmarks such as the Human dataset. The SCOPE model integrates three-dimensional protein and compound representations, graph neural networks, and bilinear attention mechanisms to effectively capture cross domain interaction patterns and outperform state-of-the-art methods across various DTI prediction tasks. Additionally, SCOPE-DTI provides a user-friendly interface and database. We further demonstrate its effectiveness by experimentally identifying anticancer targets of two bioactive natural compounds. By offering comprehensive data, advanced modeling, and accessible tools, SCOPE-DTI accelerates drug discovery research.

Introduction: Sensitive skin is characterized by a disrupted skin barrier, making it prone to reacting to external stimuli, including UV exposure, air pollution, and cosmetic allergens. Sensitive skin tends to react with oxidative stress factors that could further lead to inflammation and subsequently result in inflammaging. However, there are almost no existing inflammaging models specifically for sensitive skin, highlighting the need to develop a method for screening anti-inflammaging ingredients and products.Methods: An in vitro macrophage-fibroblast model was established to evaluate the anti-inflammaging effects of the ingredients. The M1 phenotype and aging-associated gene expression were assessed using qPCR to validate the inflammaging model. RNA sequencing was used to further elucidate the inflammaging mechanisms of the two validated ingredients.Results and conclusion: A novel in-vitro model of sensitive skin inflammaging was developed by applying the supernatant of the M1 macrophage culture medium to induce cellular senescence in fibroblast cells, facilitating the screening of anti-inflammaging ingredients. In this model, supramolecular bakuchiol could promote collagen COL1A1 and COL3A3 production and inhibit inflammatory factors by enhancing the transcription of anti-inflammatory genes (PTX3, ADAM33, and PDLIM1), while Terminalia chebula extract inhibits cell senescence by reducing the transcription of MAP4K2 and the accumulation of the inflammatory factor CCL3.

Background and Aims: Asian skin is more sensitive than Caucasian. When it comes to anti‐aging treatments, some classic actives like Retinoids, are not friendly to Asian skin due to irritation issues. Therefore, it becomes more important to research new active ingredients to address the aging concern of sensitive skin. To clinically assess the anti‐aging, skin soothing, barrier function improvement efficacy of one novel formulation containing supramolecular Bakuchiol and Terminalia chebula extract in Chinese sensitive skin population. Methods: A total of 34 sensitive skin subjects were enrolled in this clinical efficacy study. A routine consisting of twice daily topical applications of the test serum was followed for 28 days, evaluations were performed at baseline (D0) and after 8 h (T8h), 14 days (D14) and 28 days (D28) of using the regime. Objective skin assessment principles are skin sensitivity, barrier and aging. Sensitivity was evaluated by lactic acid sting test (LAST). Skin barrier evaluation, including transepidermal water loss (TEWL), a* value, and redness percentage. Aging evaluation, including wrinkle area, skin wrinkle (SEw), elasticity (R2), firmness (F4). As well as dermatologist evaluation of skin sensitivity and aging parameters and safety assessment. Results: TEWL, a* value, redness percentage and mean score of LAST significantly reduced by 24.90%, 10.76%, 31.81%, 28.09%, respectively, and Dermatologist assessment significant decrease in facial redness, after 28 days of skin care treatment with the test serum. Wrinkle area, SEw, F4 significantly reduced by 16.06%, 16.71%, 25.60%, respectively, and Dermatologist assessment significant decrease in facial wrinkles, while R2 significantly increased by 23.04% after 28 days. No adverse events were reported. Conclusions: The serum containing supramolecular Bakuchiol and Terminalia chebula extract achieved skin rejuvenation in sensitive skin by improving sensitive and aging skin.