Background/Objectives: Chest disease identification for Tuberculosis and Pneumonia diseases presents diagnostic challenges due to overlapping radiographic features and the limited availability of expert radiologists, especially in developing countries. The present study aims to address these challenges by developing a Computer-Aided Diagnosis (CAD) system to provide consistent and objective analyses of chest X-ray images, thereby reducing potential human error. By leveraging the complementary strengths of convolutional neural networks (CNNs) and vision transformers (ViTs), we propose a hybrid model for the accurate detection of Tuberculosis and for distinguishing between Tuberculosis and Pneumonia. Methods: We designed a two-step hybrid model that integrates the ResNet-50 CNN with the ViT-b16 architecture. It uses the transfer learning on datasets from Guangzhou Women’s and Children’s Medical Center for Pneumonia cases and datasets from Qatar and Dhaka (Bangladesh) universities for Tuberculosis cases. CNNs capture hierarchical structures in images, while ViTs, with their self-attention mechanisms, excel at identifying relationships between features. Combining these approaches enhances the model’s performance on binary and multi-class classification tasks. Results: Our hybrid CNN-ViT model achieved a binary classification accuracy of 98.97% for Tuberculosis detection. For multi-class classification, distinguishing between Tuberculosis, viral Pneumonia, and bacterial Pneumonia, the model achieved an accuracy of 96.18%. These results underscore the model’s potential in improving diagnostic accuracy and reliability for chest disease classification based on X-ray images. Conclusions: The proposed hybrid CNN-ViT model demonstrates substantial potential in advancing the accuracy and robustness of CAD systems for chest disease diagnosis. By integrating CNN and ViT architectures, our approach enhances the diagnostic precision, which may help to alleviate the burden on healthcare systems in resource-limited settings and improve patient outcomes in chest disease diagnosis.

Background and Objectives: Computer-aided diagnostic systems have achieved remarkable success in the medical field, particularly in diagnosing malignant tumors, and have done so at a rapid pace. However, the generalizability of the results remains a challenge for researchers and decreases the credibility of these models, which represents a point of criticism by physicians and specialists, especially given the sensitivity of the field. This study proposes a novel model based on deep learning to enhance lung cancer diagnosis quality, understandability, and generalizability. Methods: The proposed approach uses five computed tomography (CT) datasets to assess diversity and heterogeneity. Moreover, the mixup augmentation technique was adopted to facilitate the reliance on salient characteristics by combining features and CT scan labels from datasets to reduce their biases and subjectivity, thus improving the model’s generalization ability and enhancing its robustness. Curriculum learning was used to train the model, starting with simple sets to learn complicated ones quickly. Results: The proposed approach achieved promising results, with an accuracy of 99.38%; precision, specificity, and area under the curve (AUC) of 100%; sensitivity of 98.76%; and F1-score of 99.37%. Additionally, it scored a 00% false positive rate and only a 1.23% false negative rate. An external dataset was used to further validate the proposed method’s effectiveness. The proposed approach achieved optimal results of 100% in all metrics, with 00% false positive and false negative rates. Finally, explainable artificial intelligence (XAI) using Gradient-weighted Class Activation Mapping (Grad-CAM) was employed to better understand the model. Conclusions: This research proposes a robust and interpretable model for lung cancer diagnostics with improved generalizability and validity. Incorporating mixup and curriculum training supported by several datasets underlines its promise for employment as a diagnostic device in the medical industry.

Background/Objectives: In contrast to traditional biometric modalities, such as facial recognition, fingerprints, and iris scans or even DNA, the research orientation towards chest X-ray recognition has been spurred by its remarkable recognition rates. Capturing the intricate anatomical nuances of an individual’s skeletal structure, the ribcage of the chest, lungs, and heart, chest X-rays have emerged as a focal point for identification and verification, especially in the forensic field, even in scenarios where the human body damaged or disfigured. Discriminative feature embedding is essential for large-scale image verification, especially in applying chest X-ray radiographs for identity identification and verification. This study introduced a self-residual attention-based convolutional neural network (SRAN) aimed at effective feature embedding, capturing long-range dependencies and emphasizing critical spatial features in chest X-rays. This method offers a novel approach to person identification and verification through chest X-ray categorization, relevant for biometric applications and patient care, particularly when traditional biometric modalities are ineffective. Method: The SRAN architecture integrated a self-channel and self-spatial attention module to minimize channel redundancy and enhance significant spatial elements. The attention modules worked by dynamically aggregating feature maps across channel and spatial dimensions to enhance feature differentiation. For the network backbone, a self-residual attention block (SRAB) was implemented within a ResNet50 framework, forming a Siamese network trained with triplet loss to improve feature embedding for identity identification and verification. Results: By leveraging the NIH ChestX-ray14 and CheXpert datasets, our method demonstrated notable improvements in accuracy for identity verification and identification based on chest X-ray images. This approach effectively captured the detailed anatomical characteristics of individuals, including skeletal structure, ribcage, lungs, and heart, highlighting chest X-rays as a viable biometric tool even in cases of body damage or disfigurement. Conclusions: The proposed SRAN with self-residual attention provided a promising solution for biometric identification through chest X-ray imaging, showcasing its potential for accurate and reliable identity verification where traditional biometric approaches may fall short, especially in postmortem cases or forensic investigations. This methodology could play a transformative role in both biometric security and healthcare applications, offering a robust alternative modality for identity verification.