G-rich oligonucleotides (GROs) can inhibit cell proliferation by inducing cell cycle arrest at S phase in tumor cell lines. GROs bind specific cellular proteins, such as nucleolin, a crucial protein interacting with P53; however, little is known about the relationship between GROs and P53. In this study, we have shown that GROs inhibited the proliferation of U937 cells (a human monocytic leukemia cell line without P53 expression) by inducing S-phase arrest. We also showed that GRO colocalized with nucleolin in U937 cells. GRO treatment induced alteration of a series of cell cycle regulatory proteins in U937 cells. Increased Cdk2 expression might promote the cells to enter S phase and subsequent decrease of Cdk2 might induce cell cycle arrest in S phase. Transfection of U937 cells with a wild-type p53 gene caused the formation of nucleolin-P53 complex, which alleviated the effect of GRO on leukemia cells. This alleviated effect is probably due to the decreased uptake of GRO.

Purpose: The aim of this study was to investigate whether low total triiodothyronine (TT3) could affect bone turnover in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: This is a cross-sectional study that recruited 577 patients with T2DM, 141 patients formed the low TT3 group (TT3< 1.30nmol/L) and 436 patients formed the control group (TT3≥ 1.30nmol/L), and the low TT3 group was further subdivided into four groups based on the TT3 level. To investigate whether TT3 level is associated with poor glycemic control, all participants were divided into high glycosylated hemoglobin (HbA1c) group and low HbA1c group using HbA1c 10.5% as the boundary. Results: The levels of OC and PINP were significantly lower in the low TT3 group compared with the control group (P < 0.05). TT3 positively correlated with OC and PINP (r = 0.219, P = 0.009; r = 0.208, P = 0.019) in the low TT3 group, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis. Next, we want to find a cut-off point to prevent osteoporosis, we divided the patients in the low TT3 group into four groups based on the TT3 level, the levels of OC and PINP were significantly lower in the TT3 < 1.00 nmol/L group than in the TT3 ≥ 1.00 nmol/L groups. Conclusion: In patients with T2DM, low TT3 levels are associated with impaired bone formation. What’s more, bone formation was significantly impaired when TT3 was < 1.00 nmol/L.

For the infrared-laser composite seeker, the seeker fusion algorithm is studied in the simultaneous working period of the dual-mode detector. For the purpose of obtaining the control parameters under simultaneous control, make full use of the advantages of different detection performance, according to the difference of different single-mode sensors in the target recognition and tracking process under the same environment, give full play to the advantages of the same control mode information fusion algorithm, and study the information fusion process and algorithm of the multi-mode compound guidance system based simultaneous control, laying the foundation for subsequent engineering applications.