Alexander Lyndsay

Dr. Alexander Lyndsay


Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 April 2024 in Journal of Clinical Epidemiology
Verified
Journal Article
Open access
ALAlexander Lyndsay
Alexander Lyndsay
KCKay Cooper
Kay Cooper
MPMicah D.J. Peters
Micah D.J. Peters
ATAndrea C. Tricco
Andrea C. Tricco
HKHanan Khalil
Hanan Khalil
DPDanielle Pollock
Danielle Pollock

7 February 2025 in Journal of Clinical Epidemiology
Verified
Journal Article
Open access
HKHanan Khalil
Hanan Khalil
RJR. Jia
R. Jia
ÉMÉrica Moraes
Érica Moraes
ZMZ. Munn
Z. Munn
ALAlexander Lyndsay
Alexander Lyndsay
Catrin EvansCatrin Evans
Catrin Evans
Scoping reviews have been identified as appropriate methodologies to contribute to our knowledge. The objective of this review is to summarize how scoping reviews can be used to identify research priorities. Based on our experience as evidence synthesis methodologists and researchers, the Joanna Briggs Institute (JBI) scoping review methodology group, have identified the potential roles of scoping reviews in identification of research priorities. Scoping reviews typically ask broad questions that allow researchers to obtain an overview or map of the existing evidence. Scoping reviews also incorporate multiple levels of evidence that enriches the strength of the knowledge that is gained. This value is revealed by the use of scoping reviews to contribute to and perform the following functions: 1) map a research area and identify gaps that need to be addressed; 2) prioritize research topics by identifying key issues to investigate; 3) identify the type of study designs that have been used to investigate a particular topic, and/or the range of outcomes measured following a specific intervention; 4) identify the essential contextual factors that are relevant to the study of a particular research topic; 5) identify equity issues in the research field; 6) assist in engaging stakeholders and/or experts in the field by facilitating the inclusion of these stakeholders within the research process; and 7) provide the relevant new knowledge to enhance and support applications for funding. To ensure this contribution to identifying research priorities is reliable, scoping reviews must be performed following the existing rigorous methodological processes and adhere to the currently available reporting guidelines. By doing so, scoping reviews have great potential to identify research priorities, to guide the expansion of research and the generation of new knowledge.

1 June 2007 in Spine
Verified
Journal Article
Closed access
ALAlexander Lyndsay
Alexander Lyndsay
EHElizabeth Hancock
Elizabeth Hancock
IAIoannis Agouris
Ioannis Agouris
FSFrancis W. Smith
Francis W. Smith
AMAlasdair MacSween
Alasdair MacSween
Asymptomatic volunteers underwent magnetic resonance imaging to investigate how different positions affect lumbar intervertebral discs. To quantify sagittal migration of the lumbar nucleus pulposus in 6 functional positions. Previous studies of the intervertebral disc response in the sagittal plane were limited to imaging of recumbent positions. Developments of upright magnetic resonance imaging permit investigation of functional weight-bearing positions. T2-weighted sagittal scans of the L1-L2 to L5-S1 discs were taken of 11 volunteers in standing, sitting (upright, flexed, and in extension), supine, and prone extension. Sagittal migration of the nucleus pulposus was measured (mm) as distance from anterior disc boundary to peak pixel intensity. Lumbar lordosis (Cobb angle) was measured in each position. Fifteen comparisons between positions showed significant positional effects (14 at L4-L5, L5-S1, the most mobile segments). Prone extension and supine lying induced significantly less posterior migration than sitting. Flexed and upright sitting, significantly more than standing at L4-L5, as did flexed sitting compared with extended. These results support for the first time the validity of clinical assumptions about disc behavior in functional positions: sitting postures may increase risk of posterior derangement, and prone and supine may be therapeutic for symptoms caused by posterior disc displacement.

27 September 2022 in Journal of Clinical Epidemiology
Verified
Journal Article
Closed access
HKHanan Khalil
Hanan Khalil
MPMicah D.J. Peters
Micah D.J. Peters
PMPatricia A. McInerney
Patricia A. McInerney
CGChristina M. Godfrey
Christina M. Godfrey
ALAlexander Lyndsay
Alexander Lyndsay
DPDanielle Pollock
Danielle Pollock

11 May 2023 in British Journal of Sports Medicine
Verified
Journal Article
Open access
PDF file
APAnastasia Vladimirovna Pavlova
Anastasia Vladimirovna Pavlova
JSJoanna S C Shim
Joanna S C Shim
RMRachel Moss
Rachel Moss
CMColin Maclean
Colin Maclean
DBDavid Brandie
David Brandie
PSPaul Swinton
Paul Swinton
Objective: To investigate potential moderating effects of resistance exercise dose components including intensity, volume and frequency, for the management of common tendinopathies.Design: Systematic review with meta-analysis and meta-regressions.Data sources: Including but not limited to: MEDLINE, CINAHL, SPORTDiscus, ClinicalTrials.gov and ISRCTN Registry.Eligibility criteria for selecting studies: Randomised and non-randomised controlled trials investigating resistance exercise as the dominant treatment class, reporting sufficient information regarding ≥2 components of exercise dose.Results: A total of 110 studies were included in meta-analyses (148 treatment arms (TAs), 3953 participants), reporting on five tendinopathy locations (rotator cuff: 48 TAs; Achilles: 43 TAs; lateral elbow: 29 TAs; patellar: 24 TAs; gluteal: 4 TAs). Meta-regressions provided consistent evidence of greater pooled mean effect sizes for higher intensity therapies comprising additional external resistance compared with body mass only (large effect size domains:βBodyMass: External= 0.50 (95% credible interval (CrI): 0.15 to 0.84; p=0.998); small effect size domains (βBodyMass: External= 0.04 (95% CrI: −0.21 to 0.31; p=0.619)) when combined across tendinopathy locations or analysed separately. Greater pooled mean effect sizes were also identified for the lowest frequency (less than daily) compared with mid (daily) and high frequencies (more than once per day) for both effect size domains when combined or analysed separately (p≥0.976). Evidence for associations between training volume and pooled mean effect sizes was minimal and inconsistent.Summary/conclusion: Resistance exercise dose is poorly reported within tendinopathy management literature. However, this large meta-analysis identified some consistent patterns indicating greater efficacy on average with therapies prescribing higher intensities (through inclusion of additional loads) and lower frequencies, potentially creating stronger stimuli and facilitating adequate recovery.

20 November 2024 in Children
Verified
Journal Article
Open access
PDF file
AOAnna Ogonowska-Slodownik
Anna Ogonowska-Slodownik
OJOliwia Jakubowicz
Oliwia Jakubowicz
ALAlexander Lyndsay
Alexander Lyndsay
ABAndresa R Marinho- Buzelli
Andresa R Marinho- Buzelli
CDCatherine Devion
Catherine Devion
NMNatalia Morgulec-Adamowicz
Natalia Morgulec-Adamowicz
Globally, around 1 in 10 children aged 0–17 years have moderate-to-severe disabilities. The aquatic environment provides hydrostatic and hydrodynamic characteristics that make exercise and therapy feasible for children and adolescents with disabilities. The objective of this scoping review is to understand the extent and type of evidence in relation to the use of aquatic therapy in children and adolescents with disabilities. The eligibility criteria were as follows: participants—children and/or adolescents with disabilities aged from 6 to 18 years old; concept—aquatic therapy interventions; context—any available setting. The databases searched included MEDLINE, CINAHL, EMBASE, PsycINFO, AMED, Eric, Scopus, Web of Science, Epistemonikos, and one register, Cochrane Central Register of Controlled Trials. In total, 52 reports met the inclusion criteria. Most of the studies included children/adolescents with autism spectrum disorder (ASD; 46.7%)—442 participants in 21 studies in total. The majority of interventions were based on aquatic exercise (35%). Most often, interventions were conducted for 8 weeks, with 2 sessions a week lasting 60 min. The most common type of intervention for children and adolescents with ASD and Down syndrome was swimming. Participants with attention deficit hyperactivity disorder, neuromuscular disorders, and cerebral palsy were more often treated with aquatic exercises. This scoping review could guide practitioners, clinicians, and researchers on what type, setting, and content of aquatic therapy interventions, including exercise types, intervention duration, number of sessions, frequency, facility, and provider, are used with children and adolescents with disabilities.