Atopic dermatitis (AD) is one of the forms of allergic dermatitis and the most common chronic recurring inflammatory skin disease. In case of allergic dermatitis, oxidative stress (OS) promotes inflammation, disrupts the skin’s barrier function, and facilitates the penetration of allergens into the body. As a result, studying oxidative stress and its influence on the course and spread of these diseases is important in the search for new treatment strategies. This literature review aims to discover the effect of oxidative stress on the course of atopic dermatitis and review additional options for treatment. A comprehensive literature review was performed using the medical databases “PubMed” and the specialized search engine “Google Scholar” using the PICO model. Analyzed scientific articles were published from 2019 to 2024 in English. Of the 167 initial studies, 51 articles were included based on relevance, language, and release date. The other 116 articles were rejected due to incomplete publications and publications involving animals. Key biomarkers are associated with oxidative stress, including urinary 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), glutathione, and glutathione disulfide, and they correlate directly with the severity of atopic dermatitis. This research emphasizes that antioxidants, such as vitamins, sun protection, coenzyme Q10, a balanced diet, melatonin, flavonoids, and NB-UVB therapy may have a positive impact on the pathogenesis and progression of atopic dermatitis.

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation. Oxidative stress arises when the production of free radicals exceeds the antioxidant defense system’s capacity, leading to a redox imbalance. Under oxidative stress, airway inflammation is activated, leading to airway remodeling and maintenance of bronchial hyperreactivity. Airway epithelial remodeling can cause irreversible tissue fibrosis in asthma patients, thereby contributing to a severe course of asthma. A comprehensive literature review was performed using medical database “PubMed” and specialized search engine “Google Scholar” using the PICO model. A total of 51 scientific studies published in English from 2020–2025 were analyzed. Out of the initial 561 articles, 510 articles were excluded due to incomplete articles, studies involving animals, or articles not in English. New studies show that oxidative stress can be objectively measured using various biomarkers. This research aims to provide a better understanding of how oxidative stress affects the airways of asthma patients and what information can be obtained by measuring oxidative stress biomarkers.