Antioxidants are essential compounds with diverse applications, and medicinal plants are a natural source of these biomolecules. Philodendron heleniae, a species native to the Ecuadorian Amazon, belongs to a genus renowned for its traditional therapeutic uses. Extracts from the stems and roots of several Philodendron species have been widely used to treat stress, bladder disorders, and snakebite wounds, underscoring their medicinal potential. This study investigates the volatile composition, antioxidant properties, and molecular docking of ethanolic extracts from P. heleniae, aiming to expand its applications. Phytochemical analysis revealed a rich profile of tannins, phenolic compounds, flavonoids, and terpenoids. Antioxidant assays (ABTS and DPPH) demonstrated the extract’s strong free radical scavenging capacity, comparable to the standard Trolox. GC-MS analysis identified 48 volatile and semi-volatile metabolites, predominantly phenolic compounds, terpenoids, and lipid-like molecules. Fractionation of the crude ethanolic extract into aqueous and ethanolic fractions simplifies the downstream analytical steps and facilitates the identification and the evaluation of the higher abundance of antioxidant-related metabolites. Molecular docking supported these findings, highlighting strong binding affinities of stigmasterol and desmosterol to catalase, an enzyme critical for reducing oxidative stress. These results position P. heleniae as a promising source of natural antioxidants with potential pharmaceutical applications, while emphasizing the importance of conserving Ecuador’s biodiversity and its bioactive resources.

The increasing demand for sustainable and environmentally friendly materials has prompted intensive research into developing bioplastics as viable alternatives to conventional petroleum-derived plastics. Here, we report a novel approach to bioplastic production by employing plant extract-based solvents to partially dissolve cellulose, a fundamental biopolymer precursor. Using plant-derived solvents addresses concerns surrounding the environmental impact of traditional solvent-based processes, as per the principles of green chemistry. Using computational screening, some natural products were identified from the integrated database resource MEGx. Six natural sources were selected based on their molecular weight, high pKa, and chemical classification. Thin-layer chromatography (TLC) and column chromatography confirmed the presence of molecules in the extracts. Bioplastics were prepared with 1, 3, 6, 10, and 15 wt.% plant extract concentrations. Control samples without conventional dissolved and positive controls were also studied to compare their properties with novel bioplastics. Chemical characterization and biodegradability tests were performed. Degradation in water and soil tests for 35 days showed that the biodegradability of the bioplastics with natural extracts at higher concentrations was faster than that of the control samples. By day 35, bioplastics containing 15 wt.% of the D1 W extract showed rapid degradation, with higher weight loss compared with the conventional controls. The positive control (C4), containing NaOH and glycerol, degraded more slowly than the plant extract-based formulations. Also, the test indicated that the natural dissolvent’s influence on the water uptake of the material produced a better performance than the control samples. The surfaces of the bioplastic formulations were analyzed using a scanning electron microscope (SEM) at different magnifications. The findings presented here hold promise for advancing the field of bioplastics and contributing to the sustainable utilization of plant resources for eco-friendly material production.