Regional anaesthesia has seen a resurgence of sorts since the widespread advent of ultrasound into clinical practice. The ability to access hitherto inaccessible nerves and fascial planes in the human body whilst ensuring visualisation of the needle tip during block performance has opened the proverbial floodgates leading to its widespread adoption, further supported by a growing body of evidence for its many benefits in a patient’s perioperative journey and pain management. The concomitant advancement of technology and the development of powerful simulation and artificial intelligence tools has given a much-needed impetus towards improving training and safe practice in regional anaesthesia. Methods: We performed a detailed search of databases, including PubMed Medline, Web of Science, EBSCO, Embase and the Cochrane Library, up to October 2024. Our search was conducted using phrases including (but not limited to) “history of anaesthesia”, “history of simulation”, “regional anaesthesia and simulation”, AI and “artificial intelligence and anaesthesia”.