Background/Objective: In total, 17.9% of households with children experienced food insecurity (FI) in 2023. Produce prescription interventions (PRx) are a viable intervention to address FI and improve diet quality. Few studies have explored home-delivered PRxs in children. The objective of this qualitative study is to explore the experience of a novel PRx among families with young children in households at risk of experiencing FI and diet-related chronic disease. Methods: Semi-structured interviews were conducted with caretakers after the completion of a 12-month PRx. Interviews were recorded, transcribed, and analyzed using thematic analysis to identify emergent themes. Univariate descriptive statistics were used to describe baseline demographics. Results: Twenty-five families were enrolled, from which eighteen completed the program and fifteen agreed to participate in an interview. All participants were African American women. The mean age was 30.2 (±6.4) years old, and the median household size was three. Qualitative data analysis revealed three major themes. (1) The produce delivery partially alleviated financial stress, contributing to increased produce consumption patterns; (2) the intervention positively shifted the nutrition- and cooking-related knowledge and behavior of families; and (3) familial and programmatic barriers affected participation and engagement. Conclusions: PRxs are a viable option to support families to lessen the burden of FI from financial hardship and build healthy dietary habits. These insights can inform future PRx program development, delivery, evaluation, and policy or funding decisions. Future research should examine the sustained impact of PRx on healthy eating, health outcomes among caregivers and their children, and the healthcare cost and utilization rates among PRx participants.

Health equity remains a central yet insufficiently integrated priority within lifestyle medicine (LM). Although LM offers evidence-based strategies to prevent and treat chronic disease, its impact is limited when interventions fail to account for the social determinants of health (SDOH) shaping patient behavior and access. Despite growing appreciation of the importance of screening for and addressing social drivers of health, knowledge, skills, and resource gaps remain for many LM practitioners. This innovation report synthesizes key insights from the LM2025 conference session and translates them into a practical, equity-centered framework. We propose a three-domain model emphasizing (1) prioritization of populations experiencing health disparities, (2) context-sensitive application of lifestyle interventions, and (3) delivery of culturally relevant, community-engaged care. We illustrate application through a pediatric case and highlight the Family Lifestyle Program Produce Prescription (FLiPRx) as a scalable model of health equity-driven LM. We further examine biological pathways linking social adversity to chronic disease and describe how lifestyle interventions mitigate these effects. Additionally, we highlight a multisector collaboration between a hospital, health department and churches as a model for achieving health equity. This framework offers clinicians and health systems a practical pathway to integrate equity into LM practice while advancing population health outcomes.