Panagiotis Azmanis

Dr. Panagiotis Azmanis

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Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 December 2013 in Investigative Ophthalmology & Visual Science
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FRFranziska Georgia Rauscher
Franziska Georgia Rauscher
PAPanagiotis Azmanis
Panagiotis Azmanis
NKNicole Körber
Nicole Körber
CKChristian Koch
Christian Koch
JHJens Hübel
Jens Hübel
MKMaria-Elisabeth Krautwald-Junghanns
Maria-Elisabeth Krautwald-Junghanns
Purpose.: Optical coherence tomography (OCT) is an established diagnostic tool for retinal pathologies in human eyes and has been adapted to small animal models. However, there have been only a few attempts to use OCT for examination of avian eyes, and little is known about structural details of healthy or pathologically affected retinas in living birds. Methods.: We used SD-OCT (high-resolution spectral domain OCT) to investigate eyes of various avian species including birds of prey. The birds were anesthetized by isoflurane application during OCT examination. Eyes of a common buzzard ( Buteo buteo ) could be used for a comparative analysis of OCT images and histologic/immunohistochemical examinations. Results.: We investigated 45 wild and domestic birds (25 different species, 40 g–7.7 kg body mass) without and with diverse pathologic indications (e.g., body or head trauma). Animals were generally and ophthalmologically examined, and the diagnostic findings of direct ophthalmoscopy and OCT were compared. The OCT examination revealed an increased number of animals with clinical findings and allowed a detailed assessment of structural changes in retinal and choroidal tissue compared to simple direct ophthalmoscopy. Common findings were retinal and choroidal degeneration, retinal detachment, choroidal schisis, drusen, and drusenoid changes. Histologic and immunohistochemical analysis of retinal tissue confirmed the findings of the OCT examination. Conclusions.: Spectral domain OCT of eyes in living birds is applicable and useful as a diagnostic tool in veterinary clinical practices and for vision research in general. Optical coherence tomography improves the quality of the common assessment methods in avian ophthalmology, and expands the diagnostic possibilities with respect to identification and prognosis of diseases. This will be particularly important for hereditary retinal defects, especially of precious breeding individuals, or estimation of treatment success in traumatized wild birds with the aim of release back into the wild.

17 August 2018 in Veterinary Clinical Pathology
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Masha SavelieffMasha Savelieff
Masha Savelieff
LPLucia Pappalardo
Lucia Pappalardo
PAPanagiotis Azmanis
Panagiotis Azmanis

2 January 2014 in Veterinary Quarterly
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Journal Article
Open access
PAPanagiotis Azmanis
Panagiotis Azmanis
MWMorena B. Wernick
Morena B. Wernick
JHJean-Michel Hatt
Jean-Michel Hatt
Whereas the treatment of fractures in birds has been a matter of multiple studies and reviews, comparatively little information is available for the treatment of luxations in birds. In this article, we review the current knowledge regarding the frequency, etiology, clinical presentation, diagnosis, and treatment of luxations in birds, aiming to guide the clinician in private practice as well as future research. The type, the localization, and the frequency of luxation do not follow a concrete pattern. In general, pet and aviary birds are more susceptible to leg and spinal luxations while in wild birds wing luxations are more frequently observed. Diagnosis is made on the basis of detailed orthopedic and radiographic examinations. Conservative management and coaptation has been successfully used in carpal, minor elbow, shoulder, coracoid, and metatarsophalangeal luxations. Surgical management is recommended in palatine bone, metacarpophalangeal, severe elbow, coxofemoral, stifle, and intertarsal joint luxations. The techniques, which have been applied, include arthrodesis, femoral head osteotomy, polymer rods, bone plates, and internal and external fixation in various combinations. Currently, there are no controlled studies, which underline the advantages and disadvantages of each technique.

1 March 2013 in Journal of Avian Medicine and Surgery
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Journal Article
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PAPanagiotis Azmanis
Panagiotis Azmanis
JSJulia Stenkat
Julia Stenkat
JHJens Hübel
Jens Hübel
JBJulia Böhme
Julia Böhme
MKMaria Elisabeth Krautwald-Junghanns
Maria Elisabeth Krautwald-Junghanns
VSVolker Schmidt
Volker Schmidt
A 9-year-old male timneh African grey parrot (Psittacus erithacus timneh) was presented because of inability to fly and suspected trauma. The owner also had observed dyspnea, with tail bobbing and open-beak breathing. On clinical examination, a hard, painful mass was palpable in the left proximal humerus and axillary area. Radiographs revealed a radiodense soft tissue mass of the left humerus with no bony involvement, multifocal opacities in lung and air sacs, and an enlarged spleen. An asymmetric, vascularized cyst was detected in the mass by ultrasound examination. Results of biopsy of the mass revealed multifocal cysts composed of unilayer isoprismatic cells laying in vascularized connective tissue. Because of the severity of clinical signs and the poor clinical condition, the bird was euthanatized. On postmortem examination, the findings were air sac cystadenocarcinoma involving the humeral air sac with metastases in the spleen and kidneys, atherosclerosis, pneumoconiosis, and mycotic granulomatous pneumonia and airsacculitis with isolation of Aspergillus niger.

1 March 2018 in Veterinary Parasitology
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PAPanagiotis Azmanis
Panagiotis Azmanis
ASAntonio di Somma
Antonio di Somma
LPLucia Pappalardo
Lucia Pappalardo
CSChristu-Das Silvanose
Christu-Das Silvanose
Berit BangouraBerit Bangoura
Berit Bangoura

14 October 2019 in Medical Mycology
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Journal Article
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PAPanagiotis Azmanis
Panagiotis Azmanis
LPLucia Pappalardo
Lucia Pappalardo
ZSZiad A J Sara
Ziad A J Sara
CSC Silvanose
C Silvanose
VNV Naidoo
V Naidoo
Voriconazole is one of the main azoles used to treat invasive aspergillosis in falconry raptors and birds. Despite the fact that there are studies for oral and intravenous use of voriconazole in birds, there are none for its effect after intramuscular use. Empirical use of intramuscular voriconazole in falcons, indicated quicker therapy response than the oral one. Aim of this study is to evaluate the in vivo pharmacokinetic disposition of injectable voriconazole after a single intramuscular injection in large falcons (i.e., Gyrfalcons, Saker falcons, Peregrine falcons). No clinical side effects were observed in the falcons. Absorption of voriconazole was rapid (0.5–2 hours) and reached a plasma level (>1 μg/ml) which is above the minimal inhibitory concentration (MIC) for all known Aspergillus strains. This level was maintained for 16 to 20 hours, thus indicating that a single injection of 12.5 mg/kg is not enough if T > MIC is taken into consideration. On a newer aspect, according to the AUC24 unbound: MIC parameter would be indicated that this dose would be rather sufficient for most Aspergillus strains.