Electrospun scaffolds of neat poly-ε-caprolactone (PCL), poly-ε-caprolactone/β-cyclodextrin inclusion complex (PCL/β-CD) and poly-ε-caprolactone amino derivative inclusion complex (PCL/β-CD-NH₂) were prepared by the electrospinning technique. The obtained mats were analyzed by a theoretical model using the Hartree–Fock method with an STO-3G basis set, and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), differential scanning calorimetry (DSC), confocal-Raman spectroscopy, proton nuclear magnetic resonance (¹HNMR) and contact angle measure (CA). Different mixtures of solvents, such as dimethylformamide (DMF)-tetrahydrofuran (THF), dichlormethane (DCM)-dimethyl sulfoxide (DMSO) and 2,2,2-Trifluoroethanol (TFE), were tested in the fiber preparation. The results indicate that electrospun nanofibers have a pseudorotaxane structure and when it was prepared using a 2,2,2-Trifluoroethanol (TFE) as solvent, the nanofibers were electrospun well and, with the other solvents, fibers present defects such as molten fibers and bead-like defects into the fiber structure. This work provides insights into the design of PCL/β-CD-NH₂ based scaffolds that could have applications in the biomedical field.

Today, the growth of the cosmetic industry and dramatic technological advances have led to the creation of functional cosmetical products that enhance beauty and health. Such products can be defined as topical cosmetic drugs to improve health and beauty functions or benefits. Implementing nanotechnology and advanced engineering in these products has enabled innovative product formulations and solutions. The search included organic molecules used as cosmeceuticals and nanoparticles (NPs) used in that field. As a result, this document analyses the use of organic and inorganic particles, metals, metal-oxides, and carbon-based particles. Additionally, this document includes lipid and nanoparticles solid lipid systems. In conclusion, using NPs as vehicles of active substances is a potential tool for transporting active ingredients. Finally, this review includes the nanoparticles used in cosmeceuticals while presenting the progress made and highlighting the hidden challenges associated with nanocosmeceuticals.