Background and Clinical Significance: Normal wound healing is a complex and well-organized process which involves cell migration, cell proliferation and extracellular matrix deposition. However, chronic illnesses such as diabetes can lead to the dysregulation of cellular and molecular signals during this process. Case presentation: A 58-year-old diabetic male presented with a neglected abscess in his left foot, which required two surgical debridements and negative pressure wound therapy. The local infection progressed to acute respiratory failure, necessitating ICU care. After his condition stabilized, wound management with systemic antibiotics, skin grafting, and PRP injections was implemented. The patient achieved complete wound healing by 30 days postoperatively. Conclusion: In cases requiring skin grafts, PRP can enhance graft take by stimulating wound bed vascularization, which is essential for graft survival. Faster and more robust graft integration can improve outcomes, reduce complications, and increase the likelihood of successful limb preservation.