Novel quinazolin-4(3H)-ones 4–27 were synthesized. Compounds 4, 11, and 20 showed potential anti-tumour activities. 4, 11, and 20 blocked EGFR/VEGFR-2 and triggered apoptosis. Compound 4 showed the most potent activity against EGFR/VEGFR-2.
1 November 2013 in European Journal of Medicinal Chemistry
Six phenolic compounds were isolated from the solid rice culture media of Alternaria sp., an endophyte isolated from the leaves of three desert plants, Lycium schweinfurthii Dammer (Solanaceae), Pancratium maritimum L. (Amaryllidaceae) and Cynanchum acutum L. (Apocynaceae).
Using the gas chromatography mass spectrometry method, the chemical components of essential oil from flowers of Lantana camara growing in Egypt are analyzed.