The representative SARS-CoV-2 3CL^pro inhibitors reported since 2020 and their biological activities and binding models are reviewed, providing new insights into the design and development of more effective 3CL^pro inhibitors against SARS-CoV-2.

The phenyl group is the most prevalent ring system and plays an essential role as a pharmacophore or scaffold in marketed drugs. However, the indiscriminate employment of phenyl is also a major cau... Graphical abstract

A dual-emissive tris-heteroleptic ruthenium complex is reported for the ratiometric photoluminescent detection of amyloid-β aggregation in steady and transient states.