ESTHESIONEUROBLASTOMA (ENB) is an uncommon malignant tumor originating from the olfactory neuroepithelium of the upper nasal vault first described by Berger and Luc¹ in 1924. This tumor constitutes 3% of all intranasal neoplasms and can be seen in all ages, with a peak in the second and sixth decades of life and with equal distribution between the sexes.^2,3 As a result of its anatomic origin high in the nasal cavity, most patients have nonspecific symptoms, precluding early diagnosis and leading to the development of locally advanced disease that involves the paranasal sinuses and anterior cranial fossa through the cribriform plate in a large number of patients.

NASOPHARYNGEAL carcinoma (NPC) is prevalent among populations originating from southern China and their descendants who have emigrated to other parts of the world.¹

Introduction: The impact of advanced laryngeal cancer and its extensive surgical treatments cause significant morbidity for these patients. Total laryngectomy impacts essential functions such as breathing, communication and swallowing, and may influence the quality of life as well as affecting the social life of laryngeal cancer patients. Objective: Describe the quality of life and analyze the factors associated with the reduced quality of life in patients who have undergone total laryngectomy. Method: Observational cross-sectional study was carried out to evaluate the quality of life of patients who had undergone total laryngectomy due to laryngeal cancer. The fourth version of the UW-QOL Quality of Life Assessment Questionnaire from Washington University, validated for Portuguese, was used. Results: The study population was 95 patients, and the mean composite score of the QOL was 80.4. In the subjective domains the majority of the patients (38.9%) reported they felt much better at present compared to the month before being diagnosed with cancer. When questioned about how they evaluated their health-related quality of life, there was a predominance of those who considered it good (43.2%), and most considered they had a good quality of life (46.3%) considering personal well-being. The overall quality of life was considered good to excellent by 83.2% of the patients. Patients with tracheoesophageal prosthesis reported a better quality of life, compared to patients using an electrolarynx or esophageal voice. Conclusion: The high mean value of the composite score for quality of life revealed that the patients assessed their quality of life positively. The absence of vocal emission was the only variable associated with a lower quality of life within the composite score according to the UW-QOL questionnaire.