Ludger A. Wessjohann

Prof. Dr. Ludger A. Wessjohann

Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry (IPB), Halle, Germany
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Research Focus & Metrics

Academic Career Length

38Years (1989-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2003 in Chemical Reviews
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Journal Article
Closed access
LWLudger A. Wessjohann
Ludger A. Wessjohann
WBWolfgang Brandt
Wolfgang Brandt
TTThies Thiemann
Thies Thiemann

14 September 2015 in Cell Communication and Signaling
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Journal Article
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CLClaudia Lennicke
Claudia Lennicke
JRJette Rahn
Jette Rahn
RLRudolf Lichtenfels
Rudolf Lichtenfels
LWLudger A. Wessjohann
Ludger A. Wessjohann
BSBarbara Seliger
Barbara Seliger
Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sensitive cysteine residues in enzymes and transcription factors thereby altering their activities. Depending on its intracellular concentration and localization, H2O2 exhibits either pro- or anti-apoptotic activities. In comparison to normal cells, cancer cells are characterized by an increased H2O2 production rate and an impaired redox balance thereby affecting the microenvironment as well as the anti-tumoral immune response. This article reviews the current knowledge about the intracellular production of H2O2 along with redox signaling pathways mediating either the growth or apoptosis of tumor cells. In addition it will be discussed how the targeting of H2O2-linked sources and/or signaling components involved in tumor progression and survival might lead to novel therapeutic targets.


23 January 2009 in Chemical Reviews
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Journal Article
Closed access
LWLudger A. Wessjohann
Ludger A. Wessjohann
DRDaniel G. Rivera
Daniel G. Rivera
OVOtilie E. Vercillo
Otilie E. Vercillo

1 October 2007 in Biological Chemistry
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Journal Article
Closed access
LWLudger A. Wessjohann
Ludger A. Wessjohann
ASAlex Schneider
Alex Schneider
MAMuhammad Abbas
Muhammad Abbas
WBWolfgang Brandt
Wolfgang Brandt
What makes selenoenzymes – seen from a chemist's view – so special that they cannot be substituted by just more analogous or adapted sulfur proteins? This review compiles and compares physicochemical properties of selenium and sulfur, synthetic routes to selenocysteine (Sec) and its peptides, and comparative studies of relevant thiols and selenols and their (mixed) dichalcogens, required to understand the special role of selenium in selenoproteins on the atomic molecular level. The biochemically most relevant differences are the higher polarizability of Se- and the lower pK a of SeH. The latter has a strikingly different pH-dependence than thiols, with selenols being active at much lower pH. Finally, selected typical enzymatic mechanisms which involve selenocysteine are critically discussed, also in view of the authors' own results.

Verified
Journal Article
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NONatalia Osmolovskaya
Natalia Osmolovskaya
JSJulia Shumilina
Julia Shumilina
AKAhyoung Kim
Ahyoung Kim
ADAnna Didio
Anna Didio
GTGrishina Tatiana
Grishina Tatiana
LWLudger A. Wessjohann
Ludger A. Wessjohann
Drought is one of the major stress factors affecting the growth and development of plants. In this context, drought-related losses of crop plant productivity impede sustainable agriculture all over the world. In general, plants respond to water deficits by multiple physiological and metabolic adaptations at the molecular, cellular, and organism levels. To understand the underlying mechanisms of drought tolerance, adequate stress models and arrays of reliable stress markers are required. Therefore, in this review we comprehensively address currently available models of drought stress, based on culturing plants in soil, hydroponically, or in agar culture, and critically discuss advantages and limitations of each design. We also address the methodology of drought stress characterization and discuss it in the context of real experimental approaches. Further, we highlight the trends of methodological developments in drought stress research, i.e., complementing conventional tests with quantification of phytohormones and reactive oxygen species (ROS), measuring antioxidant enzyme activities, and comprehensively profiling transcriptome, proteome, and metabolome.