Coffee genetic improvement programs have been evolving very quickly, with frequent launches of new cultivars. The adoption of these new genetic materials by rural producers requires knowledge of agronomic performance in different production systems. Thus, this research aimed to evaluate the agronomic performance of irrigated and rainfed Arabica coffee (Coffea arabica L.) cultivars in the Cerrado Mineiro region. Evaluations were conducted in experimental fields across 22 farms of Arabica coffee producers, and 11 used an irrigated production system and 11 used a rainfed system. Twelve cultivars were evaluated as follows: Catuaí Vermelho IAC 144, Bourbon Amarelo IAC J10, Topázio MG 1190, MGS Epamig 1194, Catiguá MG2, MGS Catiguá 3, MGS Ametista, Pau Brasil MG1, MGS Paraíso 2, MGS Aranãs, Sarchimor MG 8840, and IAC 125 RN. Based on grain yield, processing yield, seed density, grain size, and cup quality, agronomic performance evaluations were conducted annually for the 2019, 2020, 2021, and 2022 harvests. The results showed that the grain yield was higher in the irrigated system compared to the rainfed system. In irrigated fields, the average increases in grain yield were 38%. Irrigation improved the performance of the cultivars in terms of processing yield, although it reduced cup quality. MGS Paraíso 2 cultivar showed the best productive performance, with an average of over four harvests of 52 and 42 bags ha⁻¹ (1 bag = 60 kg) in irrigated and rainfed systems, respectively. The cultivars least responsive to irrigation were IAC 125 RN, MGS Catiguá 3, MGS Ametista, and MGS Paraíso 2, with grain yield increases of 24%, 26%, 27%, and 28%, respectively. The most responsive cultivars were MGS EPAMIG 1194, Sarchimor MG 8840, and Pau Brasil MG1, with grain yield increases of 33%, 35%, and 39%, respectively. The agronomic performance results of coffee cultivars in irrigated and rainfed production systems will allow rural producers to adopt cultivars that are more suitable for the Cerrado Mineiro region.