Despite advances in cancer treatment, breast cancer (BC) remains one of the most common cancers affecting women worldwide. This study aimed to determine serum circFBXW7, circABCB10, and circ0103552 levels and compare BC patients and healthy controls to investigate their roles in the molecular mechanism of BC and the significance of these circRNAs in BC diagnosis. The study group consisted of 92 patients with BC and 31 healthy controls. Total RNA was isolated from serum samples. Following total RNA, complementary DNA was synthesized from this material. Following complementary DNA analysis, the circRNA levels were analyzed by the qRT-PCR method. Expression levels were evaluated in ΔCt values. High ΔCt values of circFBXW7 and circ0103552 and low ΔCt values of circABCB10 were correlated with BC diagnosis (circFBXW7, p = 0.043, r = 0.183, circ0103552, p < 0.001, r = 0.321, circABCB10, p = 0.001, r = −0.291). According to Fold Change (FC) values, circFBXW7 (FC = 0.30) and circ0103552 (FC = 0.26) showed low expression in the patient group compared to the control group, while circABCB10 (FC = 11.09) showed high expression (p < 0.05, for all comparisons). We think that our study is one of the rare studies investigating the relationship between BC and serum circRNA levels. This study concludes that the significant downregulation of circFBXW7 and circ0103552 and the upregulation of circABCB10 are directly related to the diagnosis of BC and can be used for diagnosis, but further studies are needed to elucidate the molecular mechanism of the relationship between circRNAs and BC.

Early detection of breast cancer (BC) remains a challenge despite advances in screening, leading to poor prognosis in late-stage disease. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for early diagnosis. The study aimed to evaluate the diagnostic utility of serum miR-197-3p, miR-1236, and miR-1271 levels in distinguishing BC patients from healthy individuals. Serum samples from 92 BC patients and 31 healthy controls were analyzed. Total RNA was extracted, and miRNA expression levels were quantified using quantitative real-time PCR (qRT-PCR). Expression differences were assessed using the ΔCt method. Receiver Operating Characteristic (ROC) curve analysis evaluated diagnostic performance. Serum miR-197-3p levels were significantly upregulated (fold change = 8.939, p = 0.0048), while miR-1236 was downregulated (fold change = 0.112, p = 0.0029) in BC patients. miR-1271 showed no significant association. miR-1236 demonstrated superior diagnostic performance (AUC = 0.731, sensitivity = 80.7%, specificity = 51.3%) compared to miR-197-3p (AUC = 0.667, sensitivity = 67.0%, specificity = 45.6%). The combination of miR-197-3p and miR-1236 improved diagnostic accuracy (AUC = 0.842, CI: 0.764–0.936). Serum miR-197-3p and miR-1236 hold promise as complementary biomarkers for early BC detection. Larger multicenter studies are warranted to validate their clinical utility.

İschemia is an undesirable condition that arises when an organ or tissue fails to receive an adequate blood supply (Brezis et al. 1984). The insufficient delivery of blood primarily impedes the tra...