Automated positioning of transmission tower keypoints is crucial for drone-based intelligent inspection systems. This paper proposes TPKE (Transmission Pylons Keypoint Extraction), a novel framework designed to extract multiple transmission tower keypoints from LiDAR point clouds. The method targets two core components: insulator string endpoints and ground wire hanging points. For insulator positioning, TPKE introduces adaptive density clustering, a morphological “concavity” index (η) for V-shaped insulators, and a “positioning-verification-compensation” strategy for handling missing data. For ground wire positioning, it combines local geometric feature analysis with spatial orthogonal projection. Using semantic segmentation for preprocessing, the framework reliably identifies components from complex transmission corridor point clouds. Validated on 1427 towers across 14 types, TPKE achieves an MAE of 0.0747 m for insulators and 0.0696 m for ground wires. It maintains centimeter-level accuracy even under challenging conditions like sparse point clouds. With an average processing time of 3.03 s per tower, the method demonstrates high efficiency, significantly reducing manual annotation workload while supporting autonomous navigation for transmission line maintenance.