Stereotactic body radiotherapy (SBRT) is increasingly used in the management of early stage non-small cell lung cancer (NSCLC), particularly, for patients in whom medical comorbidities preclude surgical resection. Prospective trials have demonstrated the feasibility, safety, and efficacy of this treatment modality yielding high rates of local control and overall survival with remarkably little toxicity in what is otherwise a fragile population.¹ x 1 Baumann, P, Nyman, J, Lax, I et al. Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries. Acta Oncol. 2006; 45: 787–795 Crossref | PubMed | Scopus (173) | Google Scholar See all References ^{, 2} x 2 Fukumoto, S, Shirato, H, Shimzu, S et al. Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable Stage I nonsmall cell lung carcinomas. Cancer. 2002; 95: 1546–1553 Crossref | PubMed | Scopus (112) | Google Scholar See all References ^{, 3} x 3 Lagerwaard, FJ, Haasbeek, CJ, Smit, EF, Slotman, BJ, and Senan, S. Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2008; 70: 685–692 Abstract | Full Text | Full Text PDF | PubMed | Scopus (370) | Google Scholar See all References ^{, 4} x 4 McGarry, RC, Papiez, L, Williams, M, Whitford, T, and Timmerman, RD. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys. 2005; 63: 1010–1015 Abstract | Full Text | Full Text PDF | PubMed | Scopus (366) | Google Scholar See all References ^{, 5} x 5 Nagata, Y, Takayama, K, Matsuo, Y et al. Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol Biol Phys. 2005; 63: 1427–1431 Abstract | Full Text | Full Text PDF | PubMed | Scopus (474) | Google Scholar See all References ^{, 6} x 6 Ng, AW, Tung, SY, and Wong, VY. Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer–report on clinical outcome and dose to critical organs. Radiother Oncol. 2008; 87: 24–28 Abstract | Full Text | Full Text PDF | PubMed | Scopus (51) | Google Scholar See all References ^{, 7} x 7 Nyman, J, Johansson, KA, and Hulten, U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer—mature results for medically inoperable patients. Lung Cancer. 2006; 51: 97–103 Abstract | Full Text | Full Text PDF | PubMed | Scopus (199) | Google Scholar See all References ^{, 8} x 8 Onimaru, R, Shirato, H, Shimizu, S et al. Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys. 2003; 56: 126–135 Abstract | Full Text | Full Text PDF | PubMed | Scopus (214) | Google Scholar See all References ^{, 9} x 9 Onishi, H, Shirato, H, Nagata, Y et al. Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol. 2007; 2: S94–S100 Abstract | Full Text | Full Text PDF | PubMed | Scopus (554) | Google Scholar See all References ^{, 10} x 10 Timmerman, R, McGarry, R, Yiannoutsos, C et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006; 24: 4833–4839 Crossref | PubMed | Scopus (823) | Google Scholar See all References ^{, 11} x 11 Uematsu, M, Shioda, A, Suda, A et al. Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: a 5-year experience. Int J Radiat Oncol Biol Phys. 2001; 51: 666–670 Abstract | Full Text | Full Text PDF | PubMed | Scopus (396) | Google Scholar See all References ^{, 12} x 12 Xia, T, Li, H, Sun, Q et al. Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006; 66: 117–125 Abstract | Full Text | Full Text PDF | PubMed | Scopus (212) | Google Scholar See all References ^{, 13} x 13 Zimmermann, FB, Geinitz, H, Schill, S et al. Stereotactic hypofractionated radiotherapy in stage I (T1–2 N0 M0) non-small-cell lung cancer (NSCLC). Acta Oncol. 2006; 45: 796–801 Crossref | PubMed | Scopus (105) | Google Scholar See all References