In diagnostics, photons are used in basic methods such as computed tomography (CT) and positron emission tomography (PET), which are pivotal tools for high-resolution, non-invasive tumor detection, offering insights into tumor staging and progression. Mentioned techniques facilitate early diagnosis and the planning of therapeutic strategies. However, new methods are emerging, enhancing the precision and detail of diagnostics, such as ultra-weak photon emission (UPE) imagining, two-photon fluorescence imaging, photo acoustic imaging, and others. Therapeutically, external beam radiation therapy (EBRT) uses photons to target cancer cells while minimizing harm to healthy tissue. Photodynamic therapy (PDT), which uses light-sensitive compounds activated by specific wavelengths, represents a photon-based treatment applicable to certain malignancies. Other treatments include photo thermal therapy (PTT), radio dynamic therapy (RDT), intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), and more. These constantly evolving photon-driven technologies can be used to treat a broad spectrum of cancers, such as pancreatic, prostate, breast, and skin cancers. This review article discusses the latest photon-based methods in oncology, focusing on new possibilities, solutions, perspectives, and the potential disadvantages of these approaches.