Background: Over time, there have been significant changes in the dietary patterns of the Chinese population with the emergence of ultra-processed foods (UPFs). Methods: To ascertain the changes in UPFs intake among adults in southern China, over the past two decades, the study included residents aged 18 years and older who participated in the China National Nutrition Surveys in Guangdong province in 2002, 2012, and 2022. Dietary intake data were collected via three-day 24 h dietary recalls and weighing household foods and condiments. The recorded dietary data were classified according to the NOVA classification system, and the percentage of total energy derived from each food group was calculated. Results: From 2002 to 2022, there was a notable increase in the consumption of UPFs among adults in Guangdong Province, with the percentage of UPFs intake rising from 0.88% to 8.52% (p-value < 0.001). This growth was especially pronounced among specific population groups, including the young, the better educated, and those living in highly urbanized areas. The largest increase in energy intake from UPFs was observed among students, from 0.42% to 17.26% (p-value < 0.001). The nutrient contents of UPFs in Guangdong in 2022 were found to contain a markedly higher calculated percentage of calories provided by carbohydrates in comparison to minimally processed foods (56.6% vs. 43.8%) as well as in sodium (749 mg/100 kcal vs. 29 mg/100 kcal). Conclusions: Given the increasing consumption of UPFs and the growing evidence linking these products to chronic diseases, it is important to promote healthy food intake and balanced diets through active nutritional education campaigns to prevent potential health risks that may arise.

Human papillomavirus (HPV) infection remains a critical public health challenge in China, particularly in Guangdong Province, where HPV-52, 16, and 58 genotypes predominate, and male infection rates exceed 40%. Despite the successful implementation of a government-funded school-based program that has achieved 88% HPV vaccine coverage among adolescent girls, several persistent barriers, including genotype mismatch (the free HPV vaccine covers < 50% of high-risk local strains), regional disparities (80% vs. 60% for first-dose coverage), and exclusion of males, thwart progress toward herd immunity. Financial sustainability risks pose an even more significant threat to the expansion of HPV vaccination programs, especially in Guangdong province where annual expenditures exceed CNY 200 million. This review delves into Guangdong’s pioneering efforts and proposes practical solutions: accelerating domestic multivalent HPV vaccine development, adopting gender-neutral vaccination policies, and leveraging mobile clinics for remote populations. These strategies not only provide a roadmap for China but also serve as valuable insight for other LMICs striving to overcome HPV-related inequalities.