The body’s physiology during physical injuries and diseases depends heavily on the function of acute inflammation. On the other hand, many variables, including iatrogenic, immune system deficiencies, lifestyle, and social and environmental factors, are significant in developing systemic chronic inflammation (SCI). SCI is a major contributor to many diseases and a global cause of death and disability. Therefore, in the present article, we suggest integrative strategies for preventing SCI by addressing receptor overexpression and promoting health improvement. With the objective of reducing chronic inflammation by regulating cytokines, chemokines, and receptor modulation to try to reduce the risk of developing systemic chronic inflammatory diseases (also known as chronic-degenerative diseases, such as diabetes mellitus, cancer, cardiovascular disease, stroke, chronic kidney disease, neurodegenerative disorders, autoimmune diseases, and psychiatric disorders), the strategies we suggest are dietary modifications, exercise, and meditation. Accordingly, the prevention of SCI can be approached holistically with the help of the previous strategies, which may substantially impact public health.

This manuscript presents information about the oxygen reactive species, oxidative stress, and their relationship with many widely distributed/ubiquitous illnesses. The antioxidant activity of estrogens in the organism is discussed along with the main reaction mechanisms involved in this capability. On the other hand, estrogens are endogen molecules of great importance to organisms because they participate in many physiological functions. Here are presented the single electron transfer (SET) reaction mechanism, the radical adduct formation (RAF), and the Hydrogen transfer (HT) of estrogens with the hydroperoxyl radical. The antioxidant activity of estrogens was compared against the ability of other natural antioxidants concluding with the possibility of them to work as antioxidants. The information presented here could be applied as an example in the free radical chapter on the organic chemistry class.