Physical activity is a potential protective factor against gout, but the role of exercise intensity in this context remains unclear. To overcome the limitations of observational studies in causal inference, this study employed a two-sample Mendelian randomization approach to explore the impact of different genetically proxied/predicted intensities of physical activity on serum urate concentration and the incidence of gout. Our data related to physical activity, serum urate, and gout were obtained from the UK Biobank, the Global Urate Genetics Consortium (GUGC), and the FinnGen dataset, respectively. Walking was included as representative of typical low-intensity physical activity in the analysis, and the other two types were moderate and vigorous physical activities. The estimation methods we used included the inverse-variance-weighted (IVW) method, MR-Egger regression, weighted-median method, simple-mode method, and weighted-mode method. Sensitivity analyses involved Rucker’s framework, Cochran’s Q test, funnel plots, MR-PRESSO outlier correction, and leave-one-out analysis. We found suggestive evidence from the inverse-variance-weighted method that moderate physical activity was a potential factor in reducing the incidence of gout (OR = 0.628, p = 0.034), and this association became more substantial in our subsequent sensitivity analysis (OR = 0.555, p = 0.006). However, we observed no distinctive effects of physical activity on serum urate concentration. In conclusion, our study supports some findings from observational studies and emphasizes the preventive role of moderate physical activity against gout. Given the limitations of the existing datasets, we call for future reexamination and expansion of our findings using new GWAS data.

Objectives: This study aimed to explore the effects of four days of Rhodiola Rosea (RR) supplementation on bench-press and bench-pull exercises under resting or mental fatigue conditions in young healthy individuals. Methods: Eighteen participants (seven women) visited the laboratory on five occasions separated by 7 days—one preliminary session and four experimental sessions. In the preliminary session, participants were familiarised with the Stroop and Multiple Object Tracking tests, after which their one-repetition maximum loads for bench presses and bench pulls were determined. The four experimental sessions had the same protocol, differing only in the supplement (RR or placebo) and mental task conditions (Stroop test or control video). Participants were assigned randomly and counterbalanced to each experimental condition: (I) RR and Stroop test, (II) RR and control video, (III) placebo and Stroop test, and (IV) placebo and control video. Results: The main findings indicate that RR supplementation has trivial-to-small effects in terms of mental fatigue, visuo-cognitive processing, or perceived exertion. However, RR was significantly superior to placebo on strength performance in the control video condition during some sets, as it increased the number of repetitions performed in the bench press and the fastest velocity in the bench pull. Out of 52 comparisons, 17 small effect sizes were observed, with 14 favouring RR and 3 favouring placebo, with the remaining differences being trivial. Conclusions: These results suggest that short-term RR supplementation is safe and provides its main ergogenic effects on physical performance rather than in visuo-cognitive or mental outcomes.

Short video usage poses risks to the health and academic performance of university students. Physical activity (PA) has been recommended as a potential solution to mitigate excessive short video usage and its associated consequences. However, current research has paid limited attention to the impact of PA on different short video usage behaviors. Therefore, we conducted a cross-sectional survey from April 24 to 30, 2024, to collect data and examine the relationship between PA and short video usage, with depression as a mediator, in domain-specific usage contexts (including short video usage during daytime and nighttime, during study time and leisure time, overall usage, and short video addiction). A total of 1172 students who met the inclusion criteria were included in the analysis. Our structural equation modeling analysis revealed that PA was directly associated only with reduced nighttime short video usage (β = -0.12; p < 0.05). Additionally, PA was indirectly associated with reduced short video usage during nighttime (β = -0.03; p < 0.05), study time (β = -0.03; p < 0.05), and leisure time (β = -0.04; p < 0.05), as well as lower levels of short video addiction (β = -0.06; p < 0.05), mediated by depression. However, no significant total effects were observed between PA and daytime short video usage (β = -0.02; p = 0.52) or overall usage (β = -0.04; p = 0.27). In conclusion, our findings suggest that while PA may improve short video addiction and certain specific short video usage behaviors, its actual effects may be limited due to the small effect sizes observed.

This study aims to explore the impact of the timing (day vs. night) and location (green space vs. non-green space) of outdoor physical activity on college students’ mental health. We designed a cross-sectional study based on self-reported data, asking participants to recall their physical activity and mental health status over the past month through a questionnaire. Specifically, a survey was conducted at a university in Chongqing, collecting data on outdoor physical activity and mental health indicators (including anxiety, depression, mental well-being, life satisfaction, happiness, and stress) from 418 students (75 females). The questionnaire was distributed via an online platform, allowing students to complete it using either their mobile phones or computers. The data collection took place in December 2024. The results showed that about half of the participants preferred engaging in outdoor physical activity in the nighttime, with most choosing green spaces. Regression analysis revealed that participants who engaged in outdoor physical activity at night had significantly lower anxiety levels compared to those who engaged in outdoor physical activity during the day (mean difference (MD) = −1.015; 95% CI = −1.974 to −0.055; p = 0.038). Additionally, compared to participants who engaged in outdoor physical activity in green spaces, those who engaged in physical activity in non-green spaces reported lower levels of mental well-being (MD = −1.531; 95% CI = −2.480 to −0.582; p = 0.002) and subjective happiness (MD = −0.462; 95% CI = −0.917 to −0.007; p = 0.047). Sensitivity analysis indicated that, for those who participated in nighttime activities, engaging in outdoor physical activity in green spaces was associated with higher levels of mental well-being (MD = 2.025; 95% CI = 0.810 to 0.324; p = 0.001) and happiness (MD = 0.583; 95% CI = 0.026 to 1.140; p = 0.040). Sensitivity analysis also revealed slight gender differences; however, the findings related to females should be interpreted with caution due to the insufficient sample size. Overall, despite some differences in time and location choices, engaging in outdoor physical activity at night in green spaces appears to associate with college students’ health, particularly their happiness and mental well-being. This study provides preliminary evidence of the potential benefits of nighttime green outdoor physical activity for improving college students’ mental health and offers directions for future research in this area.

This study aimed to evaluate how varying levels of information granularity affect the output variability and multidimensional quality — including Personality, Effectiveness, Safety, and Feasibility — of ChatGPT-generated training programs. A crossover design was used to compare simple and...

Background: Caffeine is widely recognized as an ergogenic aid to enhance athletic performance, yet its effects in hot environments remain relatively underexplored. Aims: To provide a comprehensive overview of the research landscape and identify research themes in this field. Methods: We systematically searched the Web of Science (WoS) and SCOPUS databases using keywords related to caffeine (e.g., caffe*), hot environments (e.g., heat, hot, or therm*), and athletic performance (e.g., cardio, endurance, or strength). The Bibliometrix package in R was used for bibliometric analysis and result visualization, while a narrative review was subsequently performed to identify research themes. Results: We found that studies examining the impact of caffeine on exercise in hot conditions are relatively sparse and have progressed slowly in recent years. Research in this domain has predominantly been concentrated within an academic network led by Professor Lawrence Armstrong. Recent contributions have been sporadically made by emerging scholars, with collaborations largely confined to a few research groups and countries. Key research themes identified include exercise performance, thermoregulation, fluid balance, physiological responses, immune responses, synergistic effects with other compounds, and the influence of individual differences. Of these, the first three themes—exercise performance, thermoregulation, and fluid balance—have received the most attention. Conclusions: Caffeine’s effects on exercise performance in hot environments have not been thoroughly studied. The existing research themes are varied, and the conclusions show considerable inconsistencies. Our study highlights the need for further research into the effects of caffeine dosage, administration methods, and population-specific variables. We also call for increased collaboration among research groups to advance scientific understanding and address the gaps in this field.