Background: Nearly 60 million people suffer from Computer vision syndrome (CVS) globally, resulting in reduced work productivity. Objectives:To determine the prevalence of the CVS, describe the working conditions, visualize ergonomic factors, and prevent measures application among university staff members.Methodology: A cross-sectional study was conducted using a semi-structured questionnairethat included a validated CVS questionnaire on university medical staff members. Results:CVSprevalence was 81.2%. Dryness, headache, feeling that sight is worsening and difficulty in focusing on near vision were the most experienced symptoms. Asignificantly higher prevalence of CVS was among females (52.3%), having a higher mean work duration (21.65 ± 7.55 years), those who frequently use a smartphone (84.9%), and spend most of the screen time during day and night (87.1%). Visual ergonomics and preventives measures application such as a correct screen level, a regular cleaning of the screen, appropriate illumination, and use of eye drops were significantly associated with negative CVS.Conclusions: These results raised the attention for the essential need for visual assessment of the university staff members for early and proper diagnosis of CVS to minimize its impact on their working performance. Accordingly, it’s recommended to organize university-based awareness programs regarding CVS for the working personnel.

Emotional intelligence (EI) is a fundamental pillar for academic and interpersonal success, particularly in demanding educational environments like medical training. Its impact on motivation, stress management, teamwork, and empathy highlights its pivotal role in fostering holistic student development and professional growth. Cultivating EI fosters ethical decision-making, enhances patient trust, and boosts professional satisfaction, thereby contributing to the development of a more compassionate and effective healthcare system. Integrating EI training into medical curricula holds significant potential for strengthening professional identity formation among future healthcare professionals. Such integration can be achieved through targeted strategies, including workshops, role-playing activities, mindfulness exercises, and reflective practices that cultivate self-awareness and empathy. These approaches equip students to effectively manage the emotional complexities of medical practice. By prioritizing the cultivation of EI, medical schools can better prepare students to address the multifaceted challenges of patient care and contribute to improved communication, collaboration, and resilience within healthcare teams. These competencies enable medical professionals to navigate the emotional demands of their profession, reducing burnout and promoting sustained engagement in their roles, as well as ultimately enhancing patient care, professional satisfaction, and the overall effectiveness of medical systems. This AMEE guide explores the impact of incorporating EI training into medical curricula on the professional identity formation of medical students. It focuses on how developing EI skills can enhance professional growth, resilience, and adaptability; thus, it is better to prepare students to handle the emotional and social challenges of the medical profession. The guide also aims to offer practical insights into enhancing medical education and professional development.

In order to assess the potential biochemical markers in the development, diagnosis, and prognosis of diabetic patient with microvascular complication represented with retinopathy, we analyzed the levels of cell-free DNA by two different techniques. The levels of cell-free GAPDH assayed by quantitative PCR were significantly higher in the plasma samples of diabetic patients with and without diabetic retinopathy than in those of the control group; thus, it is a better biomarker than nucleosomes assayed by ELISA in patients with type 2 diabetes for the early detection of development of microvasuclar complications as retinopathy.

Background: Osteoporosis is a systemic skeletal disease characterized by low bone mineral density. Vitamin D metabolism may play a pivotal role in its pathophysiology Objectives: To determine the association between Vitamin D receptor gene polymorphisms and bone density, as well as its relation to biochemical markers of bone turnover, in a healthy Saudi female population, Methods: A cross-sectional study was carried out at Taibah University, Madinah Region, Kingdom of Saudi Arabia. After receiving informed consent, blood samples from 300 subjects were collected to measure calcium, phosphorus, alkaline phosphatase, parathyroid hormone osteocalcin, and 1,25-OHD and perform genetic analysis of SNPs in vitamin D receptors (VDR) rs2228570, rs731236, and rs11568820. Results: There were significant differences between the CC, CT, and TT alleles of VDR rs2228570. Carrying the TT allele was associated with increased risks of decreased bone density and the presence of osteopenia with lower vitamin D3 levels (p≤0.001). The VDR rs731236 gene showed that CC allele carriers had significant risk of osteopenia. The AA genotype of rs11568820 showed lower levels of physical activity, bone mineral density, Z scores, serum osteocalcin, phosphorus, and parathyroid hormones. Conclusion: The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype were associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D.

Conditions of hypoandrogenism in men have been linked to insulin resistance, suggesting that alterations in normal sex steroid physiology could play a role in the pathogenesis of Type 2 diabetes mellitus (T2DM). Sex hormone-binding globulin (SHBG) gene polymorphisms may be the cause of sex steroid alteration. The aim of this work is to study the effect of SHBG gene polymorphisms on the risk of T2DM through its impact on testosterone and oestradiol level in Egyptian men. A case control study was performed in the diabetes clinic at Zagazig University Hospital on 185 males with Type 2 diabetes and their matched healthy controls. Two polymorphisms (rs6257 and rs6259) of the gene encoding SHBG were genotyped and serum levels of SHBG, testosterone and oestradiol were measured by enzyme-linked immunosorbent assay (ELISA). Carriers of rs6257 variant allele (CC or CT) and carriers of rs6259 wild allele (GG) appear to have a high risk of diabetes than carriers of other alleles (OR 2.241, 1.585 and 2.391, respectively). They also showed a significant decrease in plasma level of both SHBG and testosterone and a significant increase in oestradiol blood level compared with carriers of other alleles. Sex hormone-binding globulin gene polymorphisms at position rs6257 and rs6259 are associated with higher risk of T2DM in Egyptian men, through lowering circulating levels of SHBG and consequently, lowering testosterone and elevating oestradiol level.