Human Papillomavirus (HPV) is a virus that targets epithelial tissues. Virtually all cases of cervical cancer are related to HPV, emphasizing the importance of vaccines in prevention. Although >200 million doses have been administered worldwide, concerns persist about adverse reactions. This study evaluated the safety of the HPV vaccine and the main adverse effects. The study was registered in the PROSPERO database (CRD42023365692). The systematic searches were conducted in the PubMed, Scopus, Embase, Cochrane, Science Direct, and Web of Science databases using the search strategy "HPV" AND "vaccine" AND "safety" NOT "COVID" from 01/01/2007 to 31/12/2022. Inclusion criteria were based on the PICOT strategy, focusing on studies with humans, vaccinated populations comprising children, adolescents, and adults, and Phase II/III randomized clinical trials. The PEDro scale was used to assess the quality of the studies. Eleven articles were qualified for qualitative synthesis and meta-analysis. The results indicated that HPV vaccination was associated with increased local reactions, fatigue, and myalgia compared to the placebo. However, there were no significant differences in serious adverse events, gastrointestinal reactions, cutaneous effects, headache, or fever between the vaccine and placebo groups. Local reactions, fatigue, and myalgia were more prevalent in the HPV vaccine group; the overall safety profile of the vaccine was favorable. The HPV vaccine was deemed safe, mirroring the profile of adverse reactions seen with other vaccines. With its potential to prevent cancer, the benefits of HPV vaccination far outweigh the minimal risks.

Neural tube defects (NTDs) are the second most common congenital anomaly and have been widely associated with exposure to pesticides. This systematic review which analyzes the association between parental exposure to pesticides and NTDs was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The search strategy was designed considering the population, exposure, controls, outcomes, and study design (PECOS). The inclusion criteria were epidemiological studies involving pesticides exposure during embryonic development, written in English, Portuguese, or Spanish, and performed in 12 databases. Based on the eligibility criteria, 16 articles were selected for analysis. The most frequently assessed NTDs were anencephaly and spina bifida, with 14 studies investigating each of these conditions. The assessment of pesticide exposure was based on parental occupation and residential proximity to agricultural fields. Studies differed regarding the pesticides assessed, exposure windows, and parents exposed. Regarding the outcomes, it was observed that geographic proximity to agricultural fields and a greater association with family members exposed to pesticides were found in mothers and neonates with NTDs. In relation to occupational exposure, some articles found an association with NTDs, while others did not. Therefore, an analysis of the available evidence suggests that pesticides are a risk factor in the development of NTDs.

Objetivo: mapear as evidências científicas sobre a utilização do Modelo de Cuidado de Competência Cultural de Enfermeiros. Método: revisão de escopo, buscas realizadas em novembro de 2023, em seis bases de dados, incluindo estudos primários ou secundários, em português, inglês ou espanhol, publicados a partir de 2002. Resultados: incluídos 11 estudos, seis evidenciaram o uso do modelo no contexto assistencial e cinco, no de formação em Enfermagem. Conclusão: o Modelo de Cuidado de Competência Cultural de Enfermeiros apresenta-se como um contributo para o desenvolvimento profissional e de serviços de saúde culturalmente responsivos, pois seus constructos subsidiam a autopercepção dos enfermeiros como seres culturais, a busca pelo conhecimento e desenvolvimento de habilidades sobre diferentes culturas, proporcionando que os encontros de cuidado sejam permeados pela tomada de decisão e o agir profissional em consideração à diversidade étnico-cultural.

Objetivo: Descrever o processo de desenvolvimento da competência cultural vivenciado por enfermeiros no cuidado à mulher-mãe e seu filho, à luz dos constructos do Modelo de Cuidado de Competência Cultural de Enfermeiros. Método: Estudo qualitativo realizado por meio de entrevista semiestruturada e análise temática com classificação hierárquica descendente, apoiada no uso do software IRAMUTEQ®. Resultados: Participaram 20 enfermeiros que prestavam cuidado direto e indireto à mulher-mãe e filho e foram identificadas seis classes distintas, as quais receberam a nomenclatura apoiada no referencial teórico adotado. Conclusão: O desenvolvimento da competência cultural de enfermeiros inicia-se fundamentalmente com o desejo genuíno de cuidar de mulheres-mães e seus filhos com diversidade étnico-cultural, com consciência sobre a própria cultura, buscando conhecer e levantar informações de forma habilidosa que visem à avaliação de enfermagem adequada, contornando as barreiras estruturais e comunicacionais que se apresentam no encontro entre o enfermeiro e a mulher-mãe com seu filho hospitalizado.