Objective : Postoperative data on Cushing’s disease (CD) are equivocal in the literature. These discrepancies may be attributed to different series with different criteria for remission and variable follow-up durations. Additional data from experienced centers may address these discrepancies. In this study, we present the results obtained from 96 endoscopic transsphenoidal surgeries (ETSSs) for CD conducted in a well-experienced center.Methods : Pre- and postoperative data of 96 ETSS in 87 patients with CD were included. All cases were handled by the same neurosurgical team between 2014 and 2022. We obtained data on remission status 3−6 months postoperatively (medium-term) and during the latest follow-up (long-term). Additionally, magnetic resonance imaging (MRI) and pathology results were obtained for each case.Results : The mean follow-up duration was 39.5±3.2 months. Medium and long-term remission rates were 77% and 82%, respectively. When only first-time operations were considered, the medium- and long-term remission rates were 78% and 82%, respectively. The recurrence rate in this series was 2.5%. Patients who showed remission between 3−6 months had higher longterm remission rates than did those without initial remission. Tumors >2 cm and extended tumor invasion of the cavernous sinus (Knosp 4) were associated with lower postoperative remission rates.Conclusion : Adenoma size and the presence/absence of cavernous sinus invasion on preopera-tive MRI may predict long-term postoperative remission. A tumor size of 2 cm may be a supporting criterion for predicting remission in Knosp 4 tumors. Further studies with larger patient populations are necessary to support this finding.

Objective: To evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visit before the pandemic. Materials and methods: Patients of 3,903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were retrospectively scanned. The remaining 855 (656 females and 199 males) patients with active disease or who still needed multidisciplinary approaches were included. The number of patients who continued the disease-related medical procedures and [...] ABSTRACT Objective: To evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visit before the pandemic. Materials and methods: Patients of 3,903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were retrospectively scanned. The remaining 855 (656 females and 199 males) patients with active disease or who still needed multidisciplinary approaches were included. The number of patients who continued the disease-related medical procedures and

Objectives: Chronic Autoimmune Thyroiditis (AIT) is a prevalent etiology of hypothyroidism and is postulated to affect ovarian reserve (OR). Ovarian reserve in patients with hypothyroidism secondary to total thyroidectomy has not yet been specifically investigated. Anti-Mullerian hormone (AMH) is a verified and well-known biomarker reflecting OR. We aimed to investigate AMH levels in patients with hypothyroidism resulting from AIT or total thyroidectomy, and to assess the impact of both hypothyroidism and thyroid autoimmunity on ovarian reserve. Methods: A cross-sectional study conducted at Bakırköy Dr. Sadi Konuk Education and Research Hospital in Istanbul, Turkey, between June 2022-June 2024. The study cohort comprised 56 euthyroid women with established hypothyroidism (30 cases with AIT and 26 post-total thyroidectomy) and 30 age- and BMI-matched healthy women. Parameters measured included AMH, FSH,LH, estradiol, fT3, fT4, TSH, TPOAbs, and TgAbs. Results: No statistically significant difference was detected in AMH levels when comparing hypothyroid patients (irrespective of etiology) and healthy controls. Furthermore, no correlation was observed between AMH levels and TSH and/or thyroid autoantibodies. Conclusions: Regardless of the underlying etiology, women with hypothyroidism demonstrate comparable AMH concentrations of healthy women. Furthermore, thyroid autoimmunity itself does not appear to exert an additional detrimental effect on AMH.