Purpose: The literature reveals lots of information about the relationship between inflammatory markers and many diseases. In this study, we aimed to determine the relationship between erectile dysfunction and the neutrophil-lymphocyte ratio (NLR), which is a simple and nonspecific inflammatory marker. Materials and Methods: Ninety patients with erectile dysfunction (ED) and ninety-four healthy subjects were included in this study from our internal medicine and urology clinics. As diagnosis criteria, we used the first 5 questions of International Index for Erectile Function. The duration of erectile dysfunction was asked and recorded. Height, weight and waist circumference of patients were measured. We performed total blood count, sedimentation, C-reactive protein, and blood chemistry. Results: There were statistically significant differences between the control [1,038 (0,507-1,92)] and ED [59,5 (52,0-68,0)] groups in terms of NLR (P < .001). According to the multivariate logistic regression analysis, Duration of ED (Cut off: 7,5 month) predicted ED with 78,8% sensitivity and 63,1% specificity (AUC: <,001, 95% CI 1,030 (1,010-1,050), P = .003). Moreover, NLR (Cut off: 1,574) predicted ED with 81,8% sensitivity and 67,0% specificity (AUC: < 0,001, 95% CI 1,994 (1,139-3,490), P = .016) according to the multivariate logistic regression analysis. Conclusion: It was found that the neutrophil-lymphocyte ratio was higher in patient group than the control group. Also, the neutrophil-lymphocyte ratio (NLR) predicted ED and it might be helpful in diagnosing erectile dysfunction.

BACKGROUND:There is no study in the literature investigating the expression levels of WT1, p53, and IGF-1 in colon polyp subtypes. In this study, we aimed to investigate the expression levels of IGF-1, p53, and WT1 in colon polyp subtypes and to dete...

Objective: The roles of mast cells (MCs) have been demonstrated in various biologic processes in the many tumors. MCs play some roles in tumor progression via increasing angiogenesis. Tryptase and chymase are stored in the mast cell granules. The aim of this study was to investigate the relationship of tryptase and chymase in prostatic adenocarcinomas (PA). Materials and Methods: This study was conducted on a total of 134 paraffin-embedded PA samples, which were histopathologically diagnosed at the Department of Pathology of medicine Hospital between 2012 and 2014. Paraffin-embedded PA samples 3 μm in thickness, were then cut. The slides were stained with tryptase and chymase. Result : Mast Cell Chymase (MCC) was observed that intratumoral areas more acumulate than peritumoral areas (respectively; mean: 14,28 ± 14,06, mean: 12,12 ± 12,56). Mast Cell Tryptase (MCT) was more acumulated than MCC in intratumoral and peritumoral areas (P<0,001). MCT was observed that peritumoral areas more acumulate than intratumoral areas (respectively; mean: 33,94 ± 20,09, mean: 33,50 ± 18,65). MCT and MCC compared with regard to intratumoral area and peritumoral area. There wasn’t significant difference with MCT (p=0.723). However, MCC was found intratumoral area more than peritumoral area (p=0.007). Conclusion: Mast cells may play an important role for PA . MCC might be more important than MCT in malignant progression.

This study aimed to evaluate the levels of vitamin D among children and adults in Ordu, Türkiye, and to analyze variations based on age, gender, and seasonal effects. A total of 29,556 patients (7.620 children and 21.936 adults) were included in this retrospective study, with data collected from the automation system of Ordu Training and Research Hospital between April 1, 2021, and December 31, 2022. Statistical analysis was performed using Microsoft Excel and MedCalc software, employing methods such as descriptive statistics, the Mann-Whitney U test for group comparisons, and the Chi-square test for categorical data. Results indicated that vitamin D levels varied significantly based on age and gender, with 79.1% of male and 86% of female children exhibiting vitamin D deficiency (<30 ng/mL). Among adults, 89.6% of male and 92% of female patients were found to be deficient. Seasonal variations further revealed that children had higher vitamin D levels in summer compared to winter (26.3 ng/mL vs. 17.6 ng/mL). Similarly, adults showed a seasonal trend, with summer average levels being higher than winter. The findings confirm a high prevalence of vitamin D deficiency in both children and adults in Ordu. The study underscores the importance of monitoring vitamin D levels across different demographics and emphasizes the need for public health interventions, including awareness campaigns and supplementation strategies, to combat vitamin D deficiency in the region.