Coal gangue is a kind of typical by-product emitted during the coal mining and washing process. With the increase in coal resource utilization, a large amount of coal gangue was not reasonably utilized, causing environmental pollution and resource waste. The main purpose of this article is to introduce the surface structural features and compositional characteristics of coal gangue and to summarize the utilization of coal gangue in the fields of building materials, energy production, agricultural utilization, and high-value-added areas such as catalysts and adsorbents. Secondly, this review discussed the environmental challenges and technical difficulties derived from the process of coal gangue utilization and how to solve these problems through innovative methods and technological improvements. Finally, the article proposed the development direction and strategies for the future resource utilization of coal gangue, emphasizing the importance of coal gangue as a sustainable resource and its significant role in achieving a circular economy for reducing environmental pollution. By analyzing the potentiality of coal gangue for resource utilization systematically, this article aims to provide valuable references and insights for researchers and decision-makers in related fields.