Thiago Viola

Dr. Thiago Viola

orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 November 2013 in Acta Psychiatrica Scandinavica
Verified
Journal Article
Closed access
PDF file
RCR. Coelho
R. Coelho
TVThiago Viola
Thiago Viola
CWC. Walss‐Bass
C. Walss‐Bass
EBE. Brietzke
E. Brietzke
RGRodrigo Grassi-Oliveira
Rodrigo Grassi-Oliveira


1 August 2019 in Journal of Critical Care
Verified
Journal Article
Closed access
RRRegis Goulart Rosa
Regis Goulart Rosa
GFGiovanni Esteves Ferreira
Giovanni Esteves Ferreira
TVThiago Viola
Thiago Viola
CRCaroline Cabral Robinson
Caroline Cabral Robinson
RKRenata Kochhann
Renata Kochhann
CTCassiano Teixeira
Cassiano Teixeira

27 January 2014 in PLOS ONE
Verified
Journal Article
Open access
PDF file
RGRodrigo Grassi-Oliveira
Rodrigo Grassi-Oliveira
HCHugo Cogo-Moreira
Hugo Cogo-Moreira
GSGiovanni Abrahão Salum
Giovanni Abrahão Salum
EBElisa Brietzke
Elisa Brietzke
TVThiago Viola
Thiago Viola
AAAdriane Xavier Arteche
Adriane Xavier Arteche
The Childhood Trauma Questionnaire (CTQ) is internationally accepted as a key tool for the assessment of childhood abuse and neglect experiences. However, there are relative few psychometric studies available and some authors have proposed two different factor solutions. We examined the dimensional structure and internal consistency of the Brazilian version of the CTQ. A total of 1,925 participants from eight different clinical and non-clinical samples including adolescents, adults and elders were considered in this study. First, we performed Confirmatory Factor Analysis to investigate the goodness of fit of the two proposed competitive factor structure models for the CTQ. We also investigated the internal consistency of all factors. Second, multi-group analyses were used to investigate measurement invariance and population heterogeneity across age groups and sex. Our findings revealed that the alternative factor structure as opposed to the original factor structure was the most appropriate model within adolescents and adults Brazilian samples. We provide further evidence for the validity and reliability of the CTQ within the Brazilian samples and report that the alternative model showed an improvement in fit indexes and may be a better alternative over the original model.

18 February 2019 in Nature Neuroscience
Verified
Journal Article
Open access
PDF file
XLXiang Li
Xiang Li
QZQiongyi Zhao
Qiongyi Zhao
WWWei Wei
Wei Wei
QLQuan Lin
Quan Lin
CMChristophe Magnan
Christophe Magnan
TBTimothy Bredy
Timothy Bredy
DNA modification is known to regulate experience-dependent gene expression. However, beyond cytosine methylation and its oxidated derivatives, very little is known about the functional importance of chemical modifications on other nucleobases in the brain. Here we report that in adult mice trained in fear extinction, the DNA modification N6-methyl-2’-deoxyadenosine (m6dA) accumulates along promoters and coding sequences in activated prefrontal cortical neurons. The deposition of m6dA is associated with increased genome-wide occupancy of the mammalian m6dA methyltransferase, N6amt1, and this correlates with extinction-induced gene expression. The accumulation of m6dA is associated with transcriptional activation at the brain-derived neurotrophic factor (Bdnf) P4 promoter, which is required for Bdnf exon IV messenger RNA expression and for the extinction of conditioned fear. These results expand the scope of DNA modifications in the adult brain and highlight changes in m6dA as an epigenetic mechanism associated with activity-induced gene expression and the formation of fear extinction memory.

25 January 2018 in Clinical Rheumatology
Verified
Journal Article
Closed access
PDF file
LPLaura E. Petersen
Laura E. Petersen
TBTalita S. A. Baptista
Talita S. A. Baptista
JMJúlia K. Molina
Júlia K. Molina
JMJulia G. Motta
Julia G. Motta
APAline Do Prado
Aline Do Prado
Moises E. BauerMoises E. Bauer
Moises E. Bauer