Background and Objectives: Epithelial ovarian cancer (EOC) remains a significant global health challenge. While traditional prognostic factors are well established, emerging biomarkers continue to gain attention. Materials and Methods: This retrospective study evaluated the impact of systemic inflammatory markers on progression-free survival (PFS) and overall survival (OS) in 154 EOC patients. Pre-treatment neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic inflammatory index (SII) were calculated and categorized into low and high groups. Univariate and multivariate analyses were conducted to identify independent prognostic factors, while logistic regression analysis was used to determine predictors of platinum resistance. Results: In the univariate analysis, elevated NLR and PLR were associated with poorer PFS and OS. However, these markers did not maintain statistical significance in the multivariate analysis. Although SII demonstrated a trend toward worse outcomes, it did not reach statistical significance. Histopathological type, PLR, and surgical approach were identified as independent predictors of platinum resistance. Conclusions: Our findings indicate that systemic inflammatory markers may hold prognostic value in EOC; however, further validation through larger prospective studies is necessary.

Epithelial ovarian cancer (EOC) remains a significant health burden globally. While traditional prognostic factors are well-established, newer biomarkers are emerging. This retrospective study aimed to investigate the impact of systemic inflammatory markers on progression-free survival (PFS) and overall survival (OS) in 154 EOC patients. Pre-treatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammatory index (SII) were calculated and categorized into low and high groups. Univariate and multivariate analyses were performed to identify independent prognostic factors. Logistic regression analysis was used to determine predictors of platinum resistance. Elevated NLR and PLR were associated with poorer PFS and OS in univariate analysis. However, these markers did not retain their significance in multivariate analysis. SII showed a trend towards worse outcomes but did not reach statistical significance. Histopathological type, PLR, and surgical type were identified as independent predictors of platinum resistance. Our findings suggest that systemic inflammatory markers may have prognostic value in EOC, but further validation in larger prospective studies is warranted.