Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age‐related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age‐related anxiety‐like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.

Objectives: The incidence of renal cell carcinoma (RCC) has been rising, largely due to increased incidental detection from widespread imaging. Although synchronous distant metastasis (SM) with a primary renal tumor measuring <4 cm (cT1a) is uncommon, its presence may influence survival outcomes and the utility of cytoreductive nephrectomy. We sought to investigate clinical characteristics, metastatic patterns, treatments, and survival outcomes of patients with T1a RCC. Methods: All patients aged ≥18 years diagnosed with RCC between 2004 and 2019 were extracted from the National Cancer Database. The Cochran–Armitage test was used for trend analysis, while multivariable analyses were conducted to identify variables associated with SM and to assess the impact of cytoreductive surgery on mortality across isolated metastatic sites. Kaplan–Meier analysis was performed to compare survival outcomes. Results: A total of 263,911 individuals diagnosed with T1a RCC were analyzed in the study. Among them, 114,661 patients (43.4%) were classified as having cT1a tumor stage, and of these patients with cT1a RCC, 2275 (2.0%) exhibited SM. The proportion of SM cT1a was 3.39% in 2004 and 2.08% in 2019, with an Average Annual Percent Change (AAPC) of −0.037% (p = 0.830). The most common sites of metastasis were bone (59%), followed by lung (35%), liver (16%), and brain (12%). Resection of the primary tumor and receipt of systemic therapy were significantly associated with reduced mortality among all metastatic sites, especially in individuals with lung-only metastases (HR = 0.02, p = 0.013). Metastasectomy was associated with improved survival in patients with brain-only metastases (HR = 0.26, p = 0.006) but did not demonstrate the same benefit in patients with bone-, lung- or liver-only metastases. The worst 5-year OS rate was observed in cases with metastasis to multiple sites, whereas isolated metastases had similar survival rates (p < 0.0001). Our findings are limited by retrospective study design. Conclusions: This comprehensive analysis of T1a RCC patients reveals that while synchronous metastasis is relatively uncommon (2.0%), it presents significant clinical challenges, with bone as the most common metastatic site, contrasting with the typical lung predominance in larger tumors. Primary tumor resection showed survival benefit in patients with isolated metastases, especially for lung-only metastasis. These findings highlight the heterogeneous nature of tumor biology in small renal masses and underscore the importance of tailored, multimodal treatment strategies for the effective management of SM T1a RCC.

A woman in her 70s with a history of Crohn’s disease presented to the emergency department with dyspnoea, cough and intermittent fevers. Evaluation revealed a pleural effusion with neutrophil predominance, and initial suspicion of infection prompted a short course of antibiotic therapy. However, the patient subsequently developed recurrent pleural effusion with eosinophilic predominance. Serological data confirmed a diagnosis of systemic lupus erythematosus (SLE) and the patient was started on appropriate treatment. This case presents an initial manifestation of eosinophilic-dominant pleural effusion in SLE. Current guidelines in treating pleural effusions do not explore rheumatological causes. However, we believe that our case demonstrates the value of a prompt investigation for rheumatological aetiologies in an otherwise unclassified eosinophilic-predominant pleural effusion. Such an investigation should include serological data as an important confirmatory marker for the diagnosis of SLE.

Wireless communication in millimeter wave spectrum is poised to provide the latency and bandwidth needed for advanced use cases unfeasible at lower frequencies. Despite the market potential of vehicular communication networks, investigations into the millimeter wave vehicular channel are lacking. In this paper, we present a detailed overview of a novel 1 GHz wide, multi-antenna vehicle to vehicle directional channel sounding and measurement platform operating at 28 GHz. The channel sounder uses two 256-element phased arrays at the transmitter vehicle and four 64-element arrays at the receiver vehicle, with the receiver measuring 116 different directional beams in less than 1 millisecond. By measuring the full multi-beam channel impulse response at large bandwidths, our system provides unprecedented insight in instantaneous mobile vehicle to vehicle channels. The system also uses centimeter-level global position tracking and 360 degree video capture to provide additional contextual information for joint communication and sensing applications. An initial measurement campaign was conducted on highway and surface streets in Austin, Texas. We show example data that highlights the sensing capability of the system. Preliminary results from the measurement campaign show that bumper mounted mmWave arrays provide rich scattering in traffic as well a provide significant directional diversity aiding towards high reliability vehicular communication. Additionally, potential waveguide effects from high traffic in lanes can also extend the range of mmWave signals significantly.

Communication in millimeter wave spectrum is an integral component to meet the ever increasing user throughput demand in fifth generation and beyond wireless cellular networks. Current millimeter wave basestation deployments typically use active phased array antennas which employ a codebook of predetermined directional beams to service cellular users. Highly directional beams are needed to overcome the high pathloss of the wireless medium in millimeter wave spectrum. However, drawbacks of such antenna systems include the signaling and measurement overhead required to select appropriate beams from the codebook for each user, as well as grouping users that can be covered by the same beam across the operating band of the array. Digital and hybrid beamforming systems are being actively researched to overcome these issues, however there is a scarcity of multi-antenna channel measurements in the millimeter wave spectrum needed to effectively optimize digital beamforming design parameters. In this paper, we present a novel fully digital 32 channel uniform planar array testbed, that is capable of performing wideband outdoor channel measurement in millimeter wave spectrum. Our testbed can also be calibrated to maintain precise phase and amplitude synchronization across all elements of the antenna array. Preliminary results from an outdoor channel sounding campaign show that digital beamforming receive algorithms provide significantly higher beamforming gain over traditional directional beamforming.