Internet of Things (IoT) is promising technology that brings tremendous benefits if used optimally. At the same time, it has resulted in an increase in cybersecurity risks due to the lack of security for IoT devices. IoT botnets, for instance, have become a critical threat; however, systematic and comprehensive studies analyzing the importance of botnet detection methods are limited in the IoT environment. Thus, this study aimed to identify, assess and provide a thoroughly review of experimental works on the research relevant to the detection of IoT botnets. To accomplish this goal, a systematic literature review (SLR), an effective method, was applied for gathering and critically reviewing research papers. This work employed three research questions on the detection methods used to detect IoT botnets, the botnet phases and the different malicious activity scenarios. The authors analyzed the nominated research and the key methods related to them. The detection methods have been classified based on the techniques used, and the authors investigated the botnet phases during which detection is accomplished. This research procedure was used to create a source of foundational knowledge of IoT botnet detection methods. As a result of this study, the authors analyzed the current research gaps and suggest future research directions.

Recently Internet of Things (IoT) attains tremendous popularity, although this promising technology leads to a variety of security obstacles. The conventional solutions do not suit the new dilemmas brought by the IoT ecosystem. Conversely, Artificial Immune Systems (AIS) is intelligent and adaptive systems mimic the human immune system which holds desirable properties for such a dynamic environment and provides an opportunity to improve IoT security. In this work, we develop a novel hybrid Deep Learning and Dendritic Cell Algorithm (DeepDCA) in the context of an Intrusion Detection System (IDS). The framework adopts Dendritic Cell Algorithm (DCA) and Self Normalizing Neural Network (SNN). The aim of this research is to classify IoT intrusion and minimize the false alarm generation. Also, automate and smooth the signal extraction phase which improves the classification performance. The proposed IDS selects the convenient set of features from the IoT-Bot dataset, performs signal categorization using the SNN then use the DCA for classification. The experimentation results show that DeepDCA performed well in detecting the IoT attacks with a high detection rate demonstrating over 98.73% accuracy and low false-positive rate. Also, we compared these results with State-of-the-art techniques, which showed that our model is capable of performing better classification tasks than SVM, NB, KNN, and MLP. We plan to carry out further experiments to verify the framework using a more challenging dataset and make further comparisons with other signal extraction approaches. Also, involve in real-time (online) attack detection.

In recent years, accumulating evidences have shown that microRNA (miRNA) plays an important role in the exploration and treatment of diseases, so detection of the associations between miRNA and disease has been drawn more and more attentions. However, traditional experimental methods have the limitations of high cost and time- consuming, a computational method can help us more systematically and effectively predict the potential miRNA-disease associations. In this work, we proposed a novel network embedding-based heterogeneous information integration method to predict miRNA-disease associations. More specifically, a heterogeneous information network is constructed by combining the known associations among lncRNA, drug, protein, disease, and miRNA. After that, the network embedding method Learning Graph Representations with Global Structural Information (GraRep) is employed to learn embeddings of nodes in heterogeneous information network. In this way, the embedding representations of miRNA and disease are integrated with the attribute information of miRNA and disease (e.g. miRNA sequence information and disease semantic similarity) to represent miRNA-disease association pairs. Finally, the Random Forest (RF) classifier is used for predicting potential miRNA-disease associations. Under the 5-fold cross validation, our method obtained 85.11% prediction accuracy with 80.41% sensitivity at the AUC of 91.25%. In addition, in case studies of three major Human diseases, 45 (Colon Neoplasms), 42 (Breast Neoplasms) and 44 (Esophageal Neoplasms) of top-50 predicted miRNAs are respectively verified by other miRNA-disease association databases. In conclusion, the experimental results suggest that our method can be a powerful and useful tool for predicting potential miRNA-disease associations.

In Internet of Things (IoT) environments, privacy and security are among some of the significant challenges. Recently, several studies have attempted to apply blockchain technology to increase IoT network security. However, the lightweight feature of IoT devices commonly fails to meet computational intensive requirements for blockchain-based security models. In this work, we propose a mechanism to address this issue. We design an IoT blockchain architecture to store device identity information in a distributed ledger. We propose a Blockchain of Things (BCoT) Gateway to facilitate the recording of authentication transactions in a blockchain network without modifying existing device hardware or applications. Furthermore, we introduce a new device recognition model that is suitable for blockchain-based identity authentication, where we employ a novel feature selection method for device traffic flow. Finally, we develop the BCoT Sentry framework as a reference implementation of our proposed method. Experiment results verify the feasibility of our proposed framework.

Self-interacting Proteins (SIPs) plays a critical role in a series of life function in most living cells. Researches on SIPs are important part of molecular biology. Although numerous SIPs data be provided, traditional experimental methods are labor-intensive, time-consuming and costly and can only yield limited results in real-world needs. Hence,it’s urgent to develop an efficient computational SIPs prediction method to fill the gap. Deep learning technologies have proven to produce subversive performance improvements in many areas, but the effectiveness of deep learning methods for SIPs prediction has not been verified. We developed a deep learning model for predicting SIPs by constructing a Stacked Long Short-Term Memory (SLSTM) neural network that contains “dropout”. We extracted features from protein sequences using a novel feature extraction scheme that combined Zernike Moments (ZMs) with Position Specific Weight Matrix (PSWM). The capability of the proposed approach was assessed on S.erevisiae and Human SIPs datasets. The result indicates that the approach based on deep learning can effectively resist data skew and achieve good accuracies of 95.69 and 97.88%, respectively. To demonstrate the progressiveness of deep learning, we compared the results of the SLSTM-based method and the celebrated Support Vector Machine (SVM) method and several other well-known methods on the same datasets. The results show that our method is overall superior to any of the other existing state-of-the-art techniques. As far as we know, this study first applies deep learning method to predict SIPs, and practical experimental results reveal its potential in SIPs identification.

Self-interacting proteins (SIPs) is of paramount importance in current molecular biology. There have been developed a number of traditional biological experiment methods for predicting SIPs in the past few years. However, these methods are costly, time-consuming and inefficient, and often limit their usage for predicting SIPs. Therefore, the development of computational method emerges at the times require. In this paper, we for the first time proposed a novel deep learning model which combined natural language processing (NLP) method for potential SIPs prediction from the protein sequence information. More specifically, the protein sequence is de novo assembled by k-mers. Then, we obtained the global vectors representation for each protein sequences by using natural language processing (NLP) technique. Finally, based on the knowledge of known self-interacting and non-interacting proteins, a multi-grained cascade forest model is trained to predict SIPs. Comprehensive experiments were performed on yeast and human datasets, which obtained an accuracy rate of 91.45% and 93.12%, respectively. From our evaluations, the experimental results show that the use of amino acid semantics information is very helpful for addressing the problem of sequences containing both self-interacting and non-interacting pairs of proteins. This work would have potential applications for various biological classification problems.