The entropy evaluation method of assembly stress has become a hot topic in recent years. However, the current research can only evaluate the maximum stress magnitude and stress magnitude uniformity, and it cannot evaluate the stress position distribution. In this paper, an evaluation method of stress distribution characterized by strain energy density distribution is proposed. In this method, the relative entropy is used as the evaluation index of the stress distribution difference between the error model and the ideal model. It can evaluate not only the stress magnitude, but also the stress position. On this basis, an optimization method of the precise assembly process which takes the relative entropy as the optimization objective is proposed. The stress distributions of the optical lens are evaluated, and the assembly angle of the spacer in the process of the optical lens system assembly is optimized. By comparing the stress distribution of the optimized model and the ideal model, the validity of this method is proved.