Background/Objectives: Recent researches on Mortality rate (MR) Vs Bionomic functionality (BF) in the territory of the province of Monza and Milan led to the knowledge of the state of the environment of each municipality. This study verifies the need for an anamnesis capable of highlighting the presence of Cumulative Environmental Stress (ECS) and verifies the differences between smoking and non-smoking patients in their relationship with the living environment. Methods: Two questionnaires collected the patients' responses. Their evaluation is based on the cumulative impact of stress due to an incorrect Cumulative Wrong Relationships (cWR), detected through Physio-Environmental parameters (Wrong Relationships (WR-Phys)) increased by the stress due to the Wrong Relationships "Psychosocial" environment (WR-PSoc). These tables were tested in the Pneumology department of the Vimercate Hospital (Monza-Brianza) in 70 lung cancer patients. cWR receives a further cumulative impact from the bionomic conditions of the landscape unit where the patient lives, measurable by BF, leading to ECS. Results: All cases present a high ECS (above the norm), so a correlation emerges between the disease and the patient-environment relationship. An indication of morbidity is related to ECS levels. Smoker and ex-smoker patients differ from non-smoker in oncological histotypes independently from BF levels, and the ECS values of smoker are higher due to the heavy WR-PSoc factors. Conclusions: The examined patients present a high ECS, so, the distorted human-environment relationship is also accompanied by severe illnesses. Anamnesis’ extension to environmental parameters is to be suggested, also as a prevention factor.