Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation to tumors while sparing surrounding healthy tissues. Despite its clinical success, proton therapy faces challenges in optimizing its therapeutic precision and efficacy. Recent research has highlighted the potential of gold nanoparticles to enhance proton therapy outcomes. Due to their high atomic number and favorable biological properties, gold nanoparticles act as radiosensitizers by amplifying the generation of secondary electrons and reactive oxygen species upon proton irradiation. This enhances DNA damage in tumor cells while preserving healthy tissues. Additionally, functionalization of gold nanoparticles with tumor-targeting ligands offers improved precision, making proton therapy more effective against a broader range of cancers. This review synthesizes current knowledge on the mechanisms of gold nanoparticle radiosensitization, preclinical evidence, and the technological hurdles that must be addressed to integrate this promising approach into clinical practice, aiming to advance the efficacy and accessibility of proton therapy in cancer therapy.

With the main objective being to develop photochromic smart textiles, in this paper, we studied the photochromic behavior of WO_3-x nanocrystals (NCs) cooperatively interacting with variable amounts of TiO₂ NCs. We tested several blends of WO_3-x:TiO₂ NCs, admixed in different compositions (relative molar ratio of 4:0, 3:1, 2:2, 1:3, 0:4) and electrostatically interfacing because of opposite values of Z-potential, for photo-induced chromogenic textiles. We further monitored the photochromic sensitivity of NC-impregnated textiles after exposure to a few solvents (i.e., methanol, ethanol, and isopropanol) or when over-coated with different polymeric matrices such as natural cellulose or ionic conductive Nafion. The optimization of the compositions of the WO_3-x:TiO₂ blends embedded in polymeric matrices, allowed the nanostructured photochromic textiles to show rapid and tunable coloration (<5 min) and bleaching kinetics (~5 in at 75 °C or 6 h at room temperature) along with good recovery and cycling stability. This study features a simple strategy for the widespread application of WO_3-x:TiO₂-based photochromic smart textiles.

Bio-based polymers are attracting great interest due to their potential for several applications in place of conventional polymers. In the field of electrochemical devices, the electrolyte is a fundamental element that determines their performance, and polymers represent good candidates for developing solid-state and gel-based electrolytes toward the development of full-solid-state devices. In this context, the fabrication and characterization of uncrosslinked and physically cross-linked collagen membranes are reported to test their potential as a polymeric matrix for the development of a gel electrolyte. The evaluation of the membrane’s stability in water and aqueous electrolyte and the mechanical characterization demonstrated that cross-linked samples showed a good compromise in terms of water absorption capability and resistance. The optical characteristics and the ionic conductivity of the cross-linked membrane, after overnight dipping in sulfuric acid solution, demonstrated the potential of the reported membrane as an electrolyte for electrochromic devices. As proof of concept, an electrochromic device was fabricated by sandwiching the membrane (after sulfuric acid dipping) between a glass/ITO/PEDOT:PSS substrate and a glass/ITO/SnO₂ substrate. The results in terms of optical modulation and kinetic performance of such a device demonstrated that the reported cross-linked collagen membrane could represent a valid candidate as a water-based gel and bio-based electrolyte for full-solid-state electrochromic devices.

Textile-based electronics represents a key technology for the development of wearable devices. Light-emitting textiles based on OLED architecture are particularly promising due to their intrinsic flexibility and possibility to be fabricated on large areas using scalable processes. Fabric planarization is one of the most critical issues in their fabrication. Here we report a fast, simple, and industrially scalable planarization method based on the transfer of surface morphological properties from silicon to fabric. A liquid resin is used as a planarization layer, and by exploiting the low roughness of a ‘guide substrate’ it is possible to replicate the smooth and uniform surface from the silicon to the planarization layer. The result is a fabric with a flat and homogeneous polymer layer on its surface, suitable for OLED fabrication. In particular, the effect of resin viscosity on the surface morphology was evaluated to obtain the best planarization layer. The best device shows high luminance and current efficiency values, even after 1000 bending cycles. We also explored the possibility of tuning the color emitted by the device by using a fluorescent fabric as a down-converting layer. Thanks to this approach, it is in principle possible to achieve white emission from a very simple device architecture.