The present study aimed to investigate the effects of different soil amendments coupled with nitrogen fertilizer on the morpho-physiological characteristics and yield of salt-tolerant rice under saline conditions. The soil amendments, i.e., S1: zeolite amendment, S2: coconut coir amendment, S3: humic acid amendment, and S0: no amendment, and fertilizer treatments, i.e., N1: urea, N2: slow-release urea, and N0: no N fertilizer, were kept in main plots and sub-plots, respectively, in a split-plot design. The salt-tolerant variety ‘Shuangliangyou 138’ was exposed to 0.3% salt irrigation water. The results showed that during the entire growth period, compared to S0, the S1 and S3 treatments increased the SPAD values by an average of 6.3%and 5.5%, respectively, the leaf area index by an average of 24.5% and 19.8%, the canopy interception rate by an average of 11.5% and 4.1%, and the aboveground biomass by an average of 36.8% and 13.9%, respectively. Moreover, under S1 and S3 conditions, the tiller number per square meter, leaf water potential, leaf water content, and chlorophyll contents were also improved under the slow-release urea than urea. Moreover, slow-release urea promoted root vitality and nutrient absorption as well as enhanced the activity of antioxidant and nitrogen metabolism enzymes than urea under the S1 and S3 conditions. In sum, the rational application of soil amendments and slow-release urea could improve the rice productivity on saline-alkali land.