Individuals with mitral valve prolapse (MVP) have exercise intolerance even without mitral valve regurgitation. Mitral valve degeneration may progress with aging. We aimed to evaluate the influence of MVP on the cardiopulmonary function (CPF) of individuals with MVP through serial follow-ups from early to late adolescence. Thirty patients with MVP receiving at least two cardiopulmonary exercise tests (CPETs) using a treadmill (MVP group) were retrospectively analyzed. Age-, sex-, and body mass index-matched healthy peers, who also had serial CPETs, were recruited as the control group. The average time from the first CPET to the last CPET was 4.28 and 4.06 years in the MVP and control groups, respectively. At the first CPET, the MVP group had a significantly lower peak rate pressure product (PRPP) than the control group (p = 0.022). At the final CEPT, the MVP group had lower peak metabolic equivalent (MET, p = 0.032) and PRPP (p = 0.031). Moreover, the MVP group had lower peak MET and PRPP as they aged, whereas healthy peers had higher peak MET (p = 0.034) and PRPP (p = 0.047) as they aged. Individuals with MVP had poorer CPF than healthy individuals as they develop from early to late adolescence. It is important for individuals with MVP to receive regular CPET follow-ups.

It is known that children and adolescents with Kawasaki disease (KD) can maintain normal cardiopulmonary fitness (CPF) after the disease’s acute stage has subsided. This study aimed to investigate whether gender differences affect CPF in children and adolescents with KD. We retrospectively reviewed a cohort of 204 participants (120 boys and 84 girls) with KD. All participants were instructed to complete a symptom-limited cardiopulmonary exercise test (CPET) adapted to assess their CPF. Based on body mass index (BMI), boys and girls were categorized into groups of underweight (19 boys and 12 girls), normal (62 boys and 59 girls), and overweight (39 boys and 13 girls). Although a similarity in body composition was found among both genders for KD subjects and normal Taiwanese peers, the percentage of overweight subjects was higher in KD boys than the normal Taiwanese boys. When comparing CPF for different BMI groups, the whole KD group showed no discrepancy, but a significantly lower peak VO2 for the overweight KD boys group was observed, representing poorer CPF. In conclusion, girls with KD had better CPF than boys, and gender stereotypes affect sports participation as well as self-efficacy, and may be contributing to poorer CPF in KD boys.

(1) Background: To assess the impact of excessive body fat on cardiorespiratory fitness (CRF) and coronary artery health in children and adolescents following acute Kawasaki disease (KD-CA). (2) Methods: A retrospective study of KD-CA patients (ages 8–16) who completed cardiopulmonary exercise testing (CPET) in the last five years. Participants were classified based on body mass index (BMI) and fat mass index (FMI) into normal and excessive adiposity groups. Coronary artery (CA) Z-scores were calculated using the Lambda-Mu-Sigma method, with peak VO2 Z-scores (peak VO2 Z-score) derived from a database of Hong Kong Chinese children and adolescents. Primary outcomes included peak VO2 Z-score, Max-Z (maximum CA Z-score), anaerobic threshold metabolic equivalent (AT MET), peak MET, and pulse oxygen. Statistical analyses were conducted to evaluate differences across groups. (3) Results: A total of 112 KD-CA patients were included (mean age: 11.71 ± 2.54 years). The mean peak VO2 Z-score was −0.63 ± 0.98. Participants with normal BMI and FMI had significantly higher pulse oxygen levels compared to those with excessive BMI and FMI (both p < 0.001). Additionally, those with normal FMI showed higher AT MET, peak MET, peak VO2 Z-score (p = 0.049), and lower Max-Z (p = 0.026) than excessive FMI participants. Boys, especially those with normal adiposity, had superior AT MET, peak MET, pulse oxygen, and Max-Z compared to girls. (4) Conclusions: Excessive adiposity in KD-CA patients is associated with reduced CRF and elevated Max CA Z-score. These findings highlight the need to monitor body composition to optimize cardiovascular health in this population.

(1) Background: Heart failure (HF) leads to functional disability and major cardiovascular events (MACEs). Cardiopulmonary exercise testing (CPET) is the gold standard for assessing aerobic capacity and prognostic stratification. This study aimed to evaluate the predischarge CPET variables in patients with acute decompensated HF and identify the submaximal CPET variables with prognostic value. (2) Methods: A retrospective cohort study was conducted at a tertiary center in Taiwan. Patients surviving their first episode of decompensated HF and undergoing predischarge CPET (February 2017 to January 2023) were analyzed. Follow-up was conducted until a MACE or administrative censoring (up to 5 years). Cox regression identified the significant predictors of MACE. (3) Results: The study included 553, 485, and 267 patients at the 3-month, 1-year, and 5-year follow-ups, respectively. MACE rates were 15.0%, 34.2%, and 50.9%. The VE/VCO2 slope was a significant predictor of MACE at all intervals. A VE/VCO2 slope >38.95 increased the risk of MACE by 2.49-fold at 3 months and 1.81-fold at 1 year (both p < 0.001). A slope > 37.35 increased the 5-year MACE risk by 1.75-fold (p = 0.002). (4) Conclusions: The VE/VCO2 slope is a significant submaximal CPET predictor of MACE in patients post-acute decompensated HF for both short- and long-term outcomes.